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Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions

Circulating tumor cells (CTCs) have garnered a lot of attention in the past few decades. Isolation of these rare cells from the billions of blood cells has been a challenge until recent times. With the advent of new sensitive technologies that permit live cell isolation and downstream genomic analys...

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Detalles Bibliográficos
Autores principales: Zhang, Zhuo, Ramnath, Nithya, Nagrath, Sunitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588111/
https://www.ncbi.nlm.nih.gov/pubmed/26484313
http://dx.doi.org/10.3389/fonc.2015.00209
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author Zhang, Zhuo
Ramnath, Nithya
Nagrath, Sunitha
author_facet Zhang, Zhuo
Ramnath, Nithya
Nagrath, Sunitha
author_sort Zhang, Zhuo
collection PubMed
description Circulating tumor cells (CTCs) have garnered a lot of attention in the past few decades. Isolation of these rare cells from the billions of blood cells has been a challenge until recent times. With the advent of new sensitive technologies that permit live cell isolation and downstream genomic analysis, the existing paradigm of CTC research has evolved to explore clinical utility of these cells. CTCs have been identified as prognostic and pharmacodynamic biomarkers in many solid tumors, including lung cancer. As a means of liquid biopsy, CTCs could play a major role in the development of personalized medicine and targeted therapies. This review discusses the state of various isolation strategies, cell separation techniques and key studies that illustrate the application of liquid biopsy to lung cancer.
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spelling pubmed-45881112015-10-19 Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions Zhang, Zhuo Ramnath, Nithya Nagrath, Sunitha Front Oncol Oncology Circulating tumor cells (CTCs) have garnered a lot of attention in the past few decades. Isolation of these rare cells from the billions of blood cells has been a challenge until recent times. With the advent of new sensitive technologies that permit live cell isolation and downstream genomic analysis, the existing paradigm of CTC research has evolved to explore clinical utility of these cells. CTCs have been identified as prognostic and pharmacodynamic biomarkers in many solid tumors, including lung cancer. As a means of liquid biopsy, CTCs could play a major role in the development of personalized medicine and targeted therapies. This review discusses the state of various isolation strategies, cell separation techniques and key studies that illustrate the application of liquid biopsy to lung cancer. Frontiers Media S.A. 2015-09-30 /pmc/articles/PMC4588111/ /pubmed/26484313 http://dx.doi.org/10.3389/fonc.2015.00209 Text en Copyright © 2015 Zhang, Ramnath and Nagrath. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Zhuo
Ramnath, Nithya
Nagrath, Sunitha
Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions
title Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions
title_full Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions
title_fullStr Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions
title_full_unstemmed Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions
title_short Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions
title_sort current status of ctcs as liquid biopsy in lung cancer and future directions
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588111/
https://www.ncbi.nlm.nih.gov/pubmed/26484313
http://dx.doi.org/10.3389/fonc.2015.00209
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