Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment

The blood–brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood–brain barrier (BBB). We will review superselective intra-arterial mannito...

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Detalles Bibliográficos
Autores principales: Rodriguez, Analiz, Tatter, Stephen B., Debinski, Waldemar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588193/
https://www.ncbi.nlm.nih.gov/pubmed/26247958
http://dx.doi.org/10.3390/pharmaceutics7030175
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author Rodriguez, Analiz
Tatter, Stephen B.
Debinski, Waldemar
author_facet Rodriguez, Analiz
Tatter, Stephen B.
Debinski, Waldemar
author_sort Rodriguez, Analiz
collection PubMed
description The blood–brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood–brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood–brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal.
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spelling pubmed-45881932015-10-08 Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment Rodriguez, Analiz Tatter, Stephen B. Debinski, Waldemar Pharmaceutics Review The blood–brain barrier remains a main hurdle to drug delivery to the brain. The prognosis of glioblastoma remains grim despite current multimodal medical management. We review neurosurgical technologies that disrupt the blood–brain barrier (BBB). We will review superselective intra-arterial mannitol infusion, focused ultrasound, laser interstitial thermotherapy, and non-thermal irreversible electroporation (NTIRE). These technologies can lead to transient BBB and blood–brain tumor barrier disruption and allow for the potential of more effective local drug delivery. Animal studies and preliminary clinical trials show promise for achieving this goal. MDPI 2015-08-03 /pmc/articles/PMC4588193/ /pubmed/26247958 http://dx.doi.org/10.3390/pharmaceutics7030175 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rodriguez, Analiz
Tatter, Stephen B.
Debinski, Waldemar
Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment
title Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment
title_full Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment
title_fullStr Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment
title_full_unstemmed Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment
title_short Neurosurgical Techniques for Disruption of the Blood–Brain Barrier for Glioblastoma Treatment
title_sort neurosurgical techniques for disruption of the blood–brain barrier for glioblastoma treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588193/
https://www.ncbi.nlm.nih.gov/pubmed/26247958
http://dx.doi.org/10.3390/pharmaceutics7030175
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AT debinskiwaldemar neurosurgicaltechniquesfordisruptionofthebloodbrainbarrierforglioblastomatreatment

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