Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions

Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model...

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Autores principales: Kamimura, Kenya, Yokoo, Takeshi, Abe, Hiroyuki, Kobayashi, Yuji, Ogawa, Kohei, Shinagawa, Yoko, Inoue, Ryosuke, Terai, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588196/
https://www.ncbi.nlm.nih.gov/pubmed/26308044
http://dx.doi.org/10.3390/pharmaceutics7030213
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author Kamimura, Kenya
Yokoo, Takeshi
Abe, Hiroyuki
Kobayashi, Yuji
Ogawa, Kohei
Shinagawa, Yoko
Inoue, Ryosuke
Terai, Shuji
author_facet Kamimura, Kenya
Yokoo, Takeshi
Abe, Hiroyuki
Kobayashi, Yuji
Ogawa, Kohei
Shinagawa, Yoko
Inoue, Ryosuke
Terai, Shuji
author_sort Kamimura, Kenya
collection PubMed
description Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application.
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spelling pubmed-45881962015-10-08 Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions Kamimura, Kenya Yokoo, Takeshi Abe, Hiroyuki Kobayashi, Yuji Ogawa, Kohei Shinagawa, Yoko Inoue, Ryosuke Terai, Shuji Pharmaceutics Review Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application. MDPI 2015-08-21 /pmc/articles/PMC4588196/ /pubmed/26308044 http://dx.doi.org/10.3390/pharmaceutics7030213 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kamimura, Kenya
Yokoo, Takeshi
Abe, Hiroyuki
Kobayashi, Yuji
Ogawa, Kohei
Shinagawa, Yoko
Inoue, Ryosuke
Terai, Shuji
Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
title Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
title_full Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
title_fullStr Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
title_full_unstemmed Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
title_short Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
title_sort image-guided hydrodynamic gene delivery: current status and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588196/
https://www.ncbi.nlm.nih.gov/pubmed/26308044
http://dx.doi.org/10.3390/pharmaceutics7030213
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