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Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions
Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588196/ https://www.ncbi.nlm.nih.gov/pubmed/26308044 http://dx.doi.org/10.3390/pharmaceutics7030213 |
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author | Kamimura, Kenya Yokoo, Takeshi Abe, Hiroyuki Kobayashi, Yuji Ogawa, Kohei Shinagawa, Yoko Inoue, Ryosuke Terai, Shuji |
author_facet | Kamimura, Kenya Yokoo, Takeshi Abe, Hiroyuki Kobayashi, Yuji Ogawa, Kohei Shinagawa, Yoko Inoue, Ryosuke Terai, Shuji |
author_sort | Kamimura, Kenya |
collection | PubMed |
description | Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application. |
format | Online Article Text |
id | pubmed-4588196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-45881962015-10-08 Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions Kamimura, Kenya Yokoo, Takeshi Abe, Hiroyuki Kobayashi, Yuji Ogawa, Kohei Shinagawa, Yoko Inoue, Ryosuke Terai, Shuji Pharmaceutics Review Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application. MDPI 2015-08-21 /pmc/articles/PMC4588196/ /pubmed/26308044 http://dx.doi.org/10.3390/pharmaceutics7030213 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kamimura, Kenya Yokoo, Takeshi Abe, Hiroyuki Kobayashi, Yuji Ogawa, Kohei Shinagawa, Yoko Inoue, Ryosuke Terai, Shuji Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions |
title | Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions |
title_full | Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions |
title_fullStr | Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions |
title_full_unstemmed | Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions |
title_short | Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions |
title_sort | image-guided hydrodynamic gene delivery: current status and future directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588196/ https://www.ncbi.nlm.nih.gov/pubmed/26308044 http://dx.doi.org/10.3390/pharmaceutics7030213 |
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