Enhancement of Blood–Brain Barrier Permeability and Delivery of Antisense Oligonucleotides or Plasmid DNA to the Brain by the Combination of Bubble Liposomes and High-Intensity Focused Ultrasound

The blood–brain barrier (BBB) is a major obstacle that prevents therapeutic drugs or genes from being delivered to the central nervous system. Therefore, it is important to develop methods to enhance the permeability of the BBB. We have developed echo-contrast gas (C(3)F(8)) entrapping liposomes (Bu...

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Detalles Bibliográficos
Autores principales: Negishi, Yoichi, Yamane, Masaya, Kurihara, Naho, Endo-Takahashi, Yoko, Sashida, Sanae, Takagi, Norio, Suzuki, Ryo, Maruyama, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588205/
https://www.ncbi.nlm.nih.gov/pubmed/26402694
http://dx.doi.org/10.3390/pharmaceutics7030344

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