Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()

We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common p...

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Detalles Bibliográficos
Autores principales: Lopez, Aurelio, Mateos, Maria-Victoria, Oriol, Albert, Valero, Marta, Martínez, Joaquín, Lorenzo, Jose Ignacio, Perez, Montserrat, Martinez, Rafael, de Paz, Raquel, Granell, Miguel, De Arriba, Felipe, Blanchard, M. Jesús, Peñalver, Francisco Javier, Bello, Jose Luis, Martin, Maria Luisa, Bargay, Joan, Blade, Joan, Lahuerta, Juan Jose, San Miguel, Jesús F., de la Rubia, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588395/
https://www.ncbi.nlm.nih.gov/pubmed/26500850
http://dx.doi.org/10.1016/j.lrr.2015.09.002
Descripción
Sumario:We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).

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