Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()

We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common p...

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Autores principales: Lopez, Aurelio, Mateos, Maria-Victoria, Oriol, Albert, Valero, Marta, Martínez, Joaquín, Lorenzo, Jose Ignacio, Perez, Montserrat, Martinez, Rafael, de Paz, Raquel, Granell, Miguel, De Arriba, Felipe, Blanchard, M. Jesús, Peñalver, Francisco Javier, Bello, Jose Luis, Martin, Maria Luisa, Bargay, Joan, Blade, Joan, Lahuerta, Juan Jose, San Miguel, Jesús F., de la Rubia, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588395/
https://www.ncbi.nlm.nih.gov/pubmed/26500850
http://dx.doi.org/10.1016/j.lrr.2015.09.002
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author Lopez, Aurelio
Mateos, Maria-Victoria
Oriol, Albert
Valero, Marta
Martínez, Joaquín
Lorenzo, Jose Ignacio
Perez, Montserrat
Martinez, Rafael
de Paz, Raquel
Granell, Miguel
De Arriba, Felipe
Blanchard, M. Jesús
Peñalver, Francisco Javier
Bello, Jose Luis
Martin, Maria Luisa
Bargay, Joan
Blade, Joan
Lahuerta, Juan Jose
San Miguel, Jesús F.
de la Rubia, Javier
author_facet Lopez, Aurelio
Mateos, Maria-Victoria
Oriol, Albert
Valero, Marta
Martínez, Joaquín
Lorenzo, Jose Ignacio
Perez, Montserrat
Martinez, Rafael
de Paz, Raquel
Granell, Miguel
De Arriba, Felipe
Blanchard, M. Jesús
Peñalver, Francisco Javier
Bello, Jose Luis
Martin, Maria Luisa
Bargay, Joan
Blade, Joan
Lahuerta, Juan Jose
San Miguel, Jesús F.
de la Rubia, Javier
author_sort Lopez, Aurelio
collection PubMed
description We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007).
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spelling pubmed-45883952015-10-23 Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations() Lopez, Aurelio Mateos, Maria-Victoria Oriol, Albert Valero, Marta Martínez, Joaquín Lorenzo, Jose Ignacio Perez, Montserrat Martinez, Rafael de Paz, Raquel Granell, Miguel De Arriba, Felipe Blanchard, M. Jesús Peñalver, Francisco Javier Bello, Jose Luis Martin, Maria Luisa Bargay, Joan Blade, Joan Lahuerta, Juan Jose San Miguel, Jesús F. de la Rubia, Javier Leuk Res Rep Case Report We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P=0.037), in patients achieving CR (28.3 vs. 14.8 months; P=0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P=0.0007). Elsevier 2015-09-24 /pmc/articles/PMC4588395/ /pubmed/26500850 http://dx.doi.org/10.1016/j.lrr.2015.09.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lopez, Aurelio
Mateos, Maria-Victoria
Oriol, Albert
Valero, Marta
Martínez, Joaquín
Lorenzo, Jose Ignacio
Perez, Montserrat
Martinez, Rafael
de Paz, Raquel
Granell, Miguel
De Arriba, Felipe
Blanchard, M. Jesús
Peñalver, Francisco Javier
Bello, Jose Luis
Martin, Maria Luisa
Bargay, Joan
Blade, Joan
Lahuerta, Juan Jose
San Miguel, Jesús F.
de la Rubia, Javier
Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()
title Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()
title_full Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()
title_fullStr Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()
title_full_unstemmed Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()
title_short Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()
title_sort patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations()
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588395/
https://www.ncbi.nlm.nih.gov/pubmed/26500850
http://dx.doi.org/10.1016/j.lrr.2015.09.002
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