Cargando…

Absence of somatic mutations of the mTOR gene in differentiated thyroid cancer

Thyroid cancer is the most common endocrine malignancy with increasing incidence. Mammalian target of rapamycin (mTOR) is an important downstream mediator of phosphatidylinositol 3-kinase (PI3K/Akt) signaling and regulates cell growth, apoptosis and metabolism. The mTOR gene is frequently mutated in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murugan, Avaniyapuram Kannan, Humudh, Eman A., Qasem, Ebtesam, Al-Hindi, Hindi, Almohanna, Mai, Hassan, Zeinab Korany, Alzahrani, Ali S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588405/ https://www.ncbi.nlm.nih.gov/pubmed/26504747 http://dx.doi.org/10.1016/j.mgene.2015.08.005

Ejemplares similares

Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers
por: Murugan, Avaniyapuram Kannan, et al.
Publicado: (2021)

GPCR-mediated PI3K pathway mutations in pediatric and adult thyroid cancer
por: Murugan, Avaniyapuram Kannan, et al.
Publicado: (2019)

Classical V600E and other non-hotspot BRAF mutations in adult differentiated thyroid cancer
por: Murugan, Avaniyapuram Kannan, et al.
Publicado: (2016)

Thyroid Cancer, Neuroendocrine Tumor, Adrenal Adenoma, and Other Tumors in a Patient With a Germline PMS1 Mutation
por: Alghamdi, Balgees, et al.
Publicado: (2023)

Papillary Thyroid Cancer and a TERT Promotor Mutation-positive Paraganglioma in a Patient With a Germline SDHB Mutation
por: Alzahrani, Ali S, et al.
Publicado: (2022)

Identification and Characterization of Two Novel Oncogenic mTOR Mutations
por: Murugan, Avaniyapuram Kannan, et al.
Publicado: (2019)

THU683 TERT Promoter Mutations, But Not BRAF(V600E)Mutation, Correlate With The American Thyroid Association And TNM Staging Systems And Predict Outcome Of Differentiated Thyroid Cancer
por: Mukhtar, Noha, et al.
Publicado: (2023)

How do BRAF(V600E) and TERT promoter mutations interact with the ATA and TNM staging systems in thyroid cancer?
por: Mukhtar, Noha, et al.
Publicado: (2023)

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases
por: Murugan, Avaniyapuram Kannan, et al.
Publicado: (2021)

SARS-CoV-2 plays a pivotal role in inducing hyperthyroidism of Graves’ disease
por: Murugan, Avaniyapuram Kannan, et al.
Publicado: (2021)

Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer
por: MURUGAN, AVANIYAPURAM KANNAN, et al.
Publicado: (2013)

Histone deacetylation of NIS promoter underlies BRAF V600E-promoted NIS silencing in thyroid cancer
por: Zhang, Zongjing, et al.
Publicado: (2014)

mTOR pathway somatic variants and the molecular pathogenesis of hemimegalencephaly
por: Garcia, Camila A. B., et al.
Publicado: (2020)

Kirsten Ras* oncogene: Significance of its discovery in human cancer research
por: Tsuchida, Nobuo, et al.
Publicado: (2016)

SAT613 A Novel NF1 Mutation As The Underlying Cause Of Dysmorphic Features And Acromegaly In An Atypical Case Of Neurofibromatosis Type 1
por: Alsagheir, Osamah, et al.
Publicado: (2023)

The impact of thyroid imaging reporting and data system on the management of Bethesda III thyroid nodules()
por: Alqahtani, Saad M., et al.
Publicado: (2022)

Femoral Pathological Fracture as the First Clinical Manifestation of Papillary Thyroid Carcinoma in a Primigravida
por: Abu-Zaid, Ahmed, et al.
Publicado: (2013)

SAT631 EPAS1 Mutations In Three Adjacent Nucleotides Resulting In Different Phenotypes
por: Alswailem, Meshael, et al.
Publicado: (2023)

Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease
por: Kim, Daehong, et al.
Publicado: (2020)

APOBEC: A molecular driver in cervical cancer pathogenesis
por: Revathidevi, Sundaramoorthy, et al.
Publicado: (2021)

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor
por: Rodrik-Outmezguine, Vanessa S., et al.
Publicado: (2016)

Mutational profile and genotype/phenotype correlation of non-familial pheochromocytoma and paraganglioma
por: Albattal, Shatha, et al.
Publicado: (2019)

Efficacy of the Ketogenic Diet for Pediatric Epilepsy According to the Presence of Detectable Somatic mTOR Pathway Mutations in the Brain
por: Ko, Ara, et al.
Publicado: (2022)

Case Report: Severe Gonadal Dysgenesis Causing 46,XY Disorder of Sex Development Due to a Novel NR5A1 Variant
por: Alhamoudi, Kheloud M., et al.
Publicado: (2022)

Commentary: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
por: Renna, Maurizio
Publicado: (2016)

Single Nucleotide Polymorphism rs17849071 G/T in the PIK3CA Gene Is Inversely Associated with Follicular Thyroid Cancer and PIK3CA Amplification
por: Xing, Jeffrey C., et al.
Publicado: (2012)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer
por: Arun, Kanagaraj, et al.
Publicado: (2018)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

Building an Ensemble of Fine-Tuned Naive Bayesian Classifiers for Text Classification
por: El Hindi, Khalil, et al.
Publicado: (2018)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib
por: Hanly, Elyse K., et al.
Publicado: (2015)

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors
por: Hassan, Burhan, et al.
Publicado: (2014)

Large‐scale mitochondrial DNA deletion underlying familial multiple system atrophy of the cerebellar subtype
por: Alsemari, Abdulaziz, et al.
Publicado: (2015)

A Rare Case of Complete Heart Block in a Young Patient
por: Hindi, Zakaria, et al.
Publicado: (2018)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway
por: Yan, Wei, et al.
Publicado: (2021)

Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95
por: Frank, Daniel F., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_b977g0gj39mdsog7mqtsl4q0fq