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Adverse events in a newborn on valproate therapy due to loss-of-function mutations in CYP2C9
An increased risk of valproate-induced toxicity has been reported in children, particularly in those younger than 2 years of age. Significant variations in valproate pharmacokinetics and shifts in the metabolic pathways towards CYP2C9-dependent metabolism seem to play some role in the age-related di...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588450/ https://www.ncbi.nlm.nih.gov/pubmed/26543813 http://dx.doi.org/10.1016/j.ebcr.2015.08.006 |