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Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia
Chronic intermittent hypoxia (CIH) is a serious consequence of obstructive sleep apnoea (OSA) and has deleterious effects on central neurons and neurocognitive functions. This study examined if protocatechuic acid (PCA) could improve learning and memory functions of rats exposed to CIH conditions an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588513/ https://www.ncbi.nlm.nih.gov/pubmed/26419512 http://dx.doi.org/10.1038/srep14507 |
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author | Yin, Xue Zhang, Xiuli Lv, Changjun Li, Chunli Yu, Yan Wang, Xiaozhi Han, Fang |
author_facet | Yin, Xue Zhang, Xiuli Lv, Changjun Li, Chunli Yu, Yan Wang, Xiaozhi Han, Fang |
author_sort | Yin, Xue |
collection | PubMed |
description | Chronic intermittent hypoxia (CIH) is a serious consequence of obstructive sleep apnoea (OSA) and has deleterious effects on central neurons and neurocognitive functions. This study examined if protocatechuic acid (PCA) could improve learning and memory functions of rats exposed to CIH conditions and explore potential mechanisms. Neurocognitive functions were evaluated in male SD rats by step-through passive avoidance test and Morris water maze assay following exposure to CIH or room air conditions. Ultrastructure changes were investigated with transmission electron microscopy, and neuron apoptosis was confirmed by TUNEL assays. Ultrastructure changes were investigated with transmission electron microscope and neuron apoptosis was confirmed by TUNEL assays. The effects of PCA on oxidative stress, apoptosis, and brain IL-1β levels were investigated. Expression of Bcl-2, Bax, Cleaved Caspase-3, c-fos, SYN, BDNF and pro-BDNF were also studied along with JNK, P38 and ERK phosphorylation to elucidate the molecular mechanisms of PCA action. PCA was seen to enhance learning and memory ability, and alleviate oxidative stress, apoptosis and glial proliferation following CIH exposure in rats. In addition, PCA administration also decreased the level of IL-1β in brain and increased the expression of BDNF and SYN. We conclude that PCA administration will ameliorate CIH-induced cognitive dysfunctions. |
format | Online Article Text |
id | pubmed-4588513 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45885132015-10-13 Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia Yin, Xue Zhang, Xiuli Lv, Changjun Li, Chunli Yu, Yan Wang, Xiaozhi Han, Fang Sci Rep Article Chronic intermittent hypoxia (CIH) is a serious consequence of obstructive sleep apnoea (OSA) and has deleterious effects on central neurons and neurocognitive functions. This study examined if protocatechuic acid (PCA) could improve learning and memory functions of rats exposed to CIH conditions and explore potential mechanisms. Neurocognitive functions were evaluated in male SD rats by step-through passive avoidance test and Morris water maze assay following exposure to CIH or room air conditions. Ultrastructure changes were investigated with transmission electron microscopy, and neuron apoptosis was confirmed by TUNEL assays. Ultrastructure changes were investigated with transmission electron microscope and neuron apoptosis was confirmed by TUNEL assays. The effects of PCA on oxidative stress, apoptosis, and brain IL-1β levels were investigated. Expression of Bcl-2, Bax, Cleaved Caspase-3, c-fos, SYN, BDNF and pro-BDNF were also studied along with JNK, P38 and ERK phosphorylation to elucidate the molecular mechanisms of PCA action. PCA was seen to enhance learning and memory ability, and alleviate oxidative stress, apoptosis and glial proliferation following CIH exposure in rats. In addition, PCA administration also decreased the level of IL-1β in brain and increased the expression of BDNF and SYN. We conclude that PCA administration will ameliorate CIH-induced cognitive dysfunctions. Nature Publishing Group 2015-09-30 /pmc/articles/PMC4588513/ /pubmed/26419512 http://dx.doi.org/10.1038/srep14507 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Yin, Xue Zhang, Xiuli Lv, Changjun Li, Chunli Yu, Yan Wang, Xiaozhi Han, Fang Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia |
title | Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia |
title_full | Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia |
title_fullStr | Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia |
title_full_unstemmed | Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia |
title_short | Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia |
title_sort | protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588513/ https://www.ncbi.nlm.nih.gov/pubmed/26419512 http://dx.doi.org/10.1038/srep14507 |
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