Quantifying barcodes of dendritic spines using entropy-based metrics

Spine motility analysis has become the mainstay for investigating synaptic plasticity but is limited in its versatility requiring complex, non automatized instrumentations. We describe an entropy-based method for determining the spatial distribution of dendritic spines that allows successful estimat...

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Detalles Bibliográficos
Autores principales: Viggiano, D., Srivastava, D. P., Speranza, L., Perrone-Capano, C., Bellenchi, G. C., di Porzio, U., Buckley, N. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588562/
https://www.ncbi.nlm.nih.gov/pubmed/26419702
http://dx.doi.org/10.1038/srep14622
Descripción
Sumario:Spine motility analysis has become the mainstay for investigating synaptic plasticity but is limited in its versatility requiring complex, non automatized instrumentations. We describe an entropy-based method for determining the spatial distribution of dendritic spines that allows successful estimation of spine motility from still images. This method has the potential to extend the applicability of spine motility analysis to ex vivo preparations.

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