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Generation of an alpaca-derived nanobody recognizing γ-H2AX
Post-translational modifications are difficult to visualize in living cells and are conveniently analyzed using antibodies. Single-chain antibody fragments derived from alpacas and called nanobodies can be expressed and bind to the target antigenic sites in living cells. As a proof of concept, we ge...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588710/ https://www.ncbi.nlm.nih.gov/pubmed/26500838 http://dx.doi.org/10.1016/j.fob.2015.09.005 |