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Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation

Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling. Here, we demonstrate that TRIM25 is required for melanoma differentiation-associated gene 5 (MDA5) and MAVS mediated a...

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Detalles Bibliográficos
Autores principales:	Lee, Na-Rae, Kim, Hye-In, Choi, Myung-Soo, Yi, Chae-Min, Inn, Kyung-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588718/ https://www.ncbi.nlm.nih.gov/pubmed/26299329 http://dx.doi.org/10.14348/molcells.2015.0047

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