Anergic bone marrow Vγ9Vδ2 T cells as early and long-lasting markers of PD-1-targetable microenvironment-induced immune suppression in human myeloma

Vγ9Vδ2 T cells have a natural inclination to recognize malignant B cells in vitro via receptors for stress-induced self-ligands and TCR-dependent recognition of phosphoantigens (pAgs) generated in the mevalonate (Mev) pathway. This inclination is continuously challenged in vivo by the immune suppres...

Descripción completa

Detalles Bibliográficos
Autores principales: Castella, Barbara, Foglietta, Myriam, Sciancalepore, Patrizia, Rigoni, Micol, Coscia, Marta, Griggio, Valentina, Vitale, Candida, Ferracini, Riccardo, Saraci, Elona, Omedé, Paola, Riganti, Chiara, Palumbo, Antonio, Boccadoro, Mario, Massaia, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589055/
https://www.ncbi.nlm.nih.gov/pubmed/26451323
http://dx.doi.org/10.1080/2162402X.2015.1047580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589055/
https://www.ncbi.nlm.nih.gov/pubmed/26451323
http://dx.doi.org/10.1080/2162402X.2015.1047580

Ejemplares similares