Toward a rational design of combination therapy in cancer

By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie m...

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Detalles Bibliográficos
Autores principales: Doucey, Marie-Agnès, Xenarios, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589060/
https://www.ncbi.nlm.nih.gov/pubmed/26451320
http://dx.doi.org/10.1080/2162402X.2015.1046674
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author Doucey, Marie-Agnès
Xenarios, Ioannis
author_facet Doucey, Marie-Agnès
Xenarios, Ioannis
author_sort Doucey, Marie-Agnès
collection PubMed
description By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie monocyte pro-angiogenic activity have a strong predictive value for breast cancer patient relapse – free survival.
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spelling pubmed-45890602016-02-03 Toward a rational design of combination therapy in cancer Doucey, Marie-Agnès Xenarios, Ioannis Oncoimmunology Author's View By merging computational systems modeling and experimental approaches, we have uncovered treatments reprogramming pro-angiogenic monocytes present in breast tumor into immunologically potent cells capable of mediating an anti-tumor immune response. The unraveled pathways and ligands which underlie monocyte pro-angiogenic activity have a strong predictive value for breast cancer patient relapse – free survival. Taylor & Francis 2015-07-07 /pmc/articles/PMC4589060/ /pubmed/26451320 http://dx.doi.org/10.1080/2162402X.2015.1046674 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Doucey, Marie-Agnès
Xenarios, Ioannis
Toward a rational design of combination therapy in cancer
title Toward a rational design of combination therapy in cancer
title_full Toward a rational design of combination therapy in cancer
title_fullStr Toward a rational design of combination therapy in cancer
title_full_unstemmed Toward a rational design of combination therapy in cancer
title_short Toward a rational design of combination therapy in cancer
title_sort toward a rational design of combination therapy in cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589060/
https://www.ncbi.nlm.nih.gov/pubmed/26451320
http://dx.doi.org/10.1080/2162402X.2015.1046674
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