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A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination

BACKGROUND: Fluorescent molecular tomography (FMT) aims at reconstructing the spatial map of optical and fluorescence parameters from fluence measurements. Basically, solving large-scale matrix equations is computationally expensive for image reconstruction of FMT. Despite the reconstruction quality...

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Detalles Bibliográficos
Autores principales: Zou, Wei, Wang, Jiajun, Hu, Danfeng, Wang, Wenxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589093/
https://www.ncbi.nlm.nih.gov/pubmed/26419738
http://dx.doi.org/10.1186/s12938-015-0080-y
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author Zou, Wei
Wang, Jiajun
Hu, Danfeng
Wang, Wenxia
author_facet Zou, Wei
Wang, Jiajun
Hu, Danfeng
Wang, Wenxia
author_sort Zou, Wei
collection PubMed
description BACKGROUND: Fluorescent molecular tomography (FMT) aims at reconstructing the spatial map of optical and fluorescence parameters from fluence measurements. Basically, solving large-scale matrix equations is computationally expensive for image reconstruction of FMT. Despite the reconstruction quality can be improved with more sources, it may result in higher computational costs for reconstruction. This article presents a novel method in the wavelet domain with rotated sources illumination. METHODS: We use the finite element method for the computation of the forward model. The global inverse problem is solved based on wavelet in conjunction with principal component analysis. The iterative reconstruction is implemented with sources rotated in a certain angle. The original excitation light sources are used to reconstruct the image in the first iteration. Then, upon the sources are rotated by a certain angle, they are employed for the next iteration of reconstruction. RESULTS: Simulation results demonstrate that our method can considerably reduce the time taken for the computation of inverse problem in FMT. Furthermore, the approach proposed is also shown to largely outperform the traditional method in terms of the precision of inverse solutions. CONCLUSIONS: Our method has the capability to locate the inclusions. The proposed method can significantly speed up the reconstruction process with the high reconstruction quality.
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spelling pubmed-45890932015-10-01 A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination Zou, Wei Wang, Jiajun Hu, Danfeng Wang, Wenxia Biomed Eng Online Research BACKGROUND: Fluorescent molecular tomography (FMT) aims at reconstructing the spatial map of optical and fluorescence parameters from fluence measurements. Basically, solving large-scale matrix equations is computationally expensive for image reconstruction of FMT. Despite the reconstruction quality can be improved with more sources, it may result in higher computational costs for reconstruction. This article presents a novel method in the wavelet domain with rotated sources illumination. METHODS: We use the finite element method for the computation of the forward model. The global inverse problem is solved based on wavelet in conjunction with principal component analysis. The iterative reconstruction is implemented with sources rotated in a certain angle. The original excitation light sources are used to reconstruct the image in the first iteration. Then, upon the sources are rotated by a certain angle, they are employed for the next iteration of reconstruction. RESULTS: Simulation results demonstrate that our method can considerably reduce the time taken for the computation of inverse problem in FMT. Furthermore, the approach proposed is also shown to largely outperform the traditional method in terms of the precision of inverse solutions. CONCLUSIONS: Our method has the capability to locate the inclusions. The proposed method can significantly speed up the reconstruction process with the high reconstruction quality. BioMed Central 2015-09-30 /pmc/articles/PMC4589093/ /pubmed/26419738 http://dx.doi.org/10.1186/s12938-015-0080-y Text en © Zou et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zou, Wei
Wang, Jiajun
Hu, Danfeng
Wang, Wenxia
A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination
title A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination
title_full A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination
title_fullStr A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination
title_full_unstemmed A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination
title_short A reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination
title_sort reconstruction approach in wavelet domain for fluorescent molecular tomography via rotated sources illumination
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589093/
https://www.ncbi.nlm.nih.gov/pubmed/26419738
http://dx.doi.org/10.1186/s12938-015-0080-y
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