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Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey

BACKGROUND: Studies investigating the association between telomere length and diabetes have been inconsistent, and there are few data available investigating the associations of telomere length with diabetes duration and control. We evaluated the relationship of leukocyte telomere length with diabet...

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Autores principales: Menke, Andy, Casagrande, Sarah, Cowie, Catherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589193/
https://www.ncbi.nlm.nih.gov/pubmed/26419237
http://dx.doi.org/10.1186/s12902-015-0050-1
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author Menke, Andy
Casagrande, Sarah
Cowie, Catherine C.
author_facet Menke, Andy
Casagrande, Sarah
Cowie, Catherine C.
author_sort Menke, Andy
collection PubMed
description BACKGROUND: Studies investigating the association between telomere length and diabetes have been inconsistent, and there are few data available investigating the associations of telomere length with diabetes duration and control. We evaluated the relationship of leukocyte telomere length with diabetes, and the relationship of leukocyte telomere length with diabetes duration and poor glucose control among people with diabetes. METHODS: We used data from the 1999–2002 National Health and Nutrition Examination Survey, a representative sample of the US civilian non-institutionalized population. In 3921 participants, leukocyte telomere length was measured and diabetes status was determined based on a previous diagnosis, hemoglobin A1c ≥6.5 %, or fasting glucose ≥126 mg/dL. RESULTS: The odds ratios (95 % confidence intervals) of diabetes associated with the first, second, and third quartile of leukocyte telomere length, compared to the highest quartile, was 2.09 (1.46–2.98), 1.74 (1.30–2.31), and 1.08 (0.76–1.54), respectively (p-trend < 0.01), in unadjusted models and 0.74 (0.48–1.14), 0.91 (0.61–1.34), and 0.87 (0.59–1.29), respectively (p-trend = 0.20), in multivariable adjusted models. Among participants with diabetes, unadjusted and adjusted leukocyte telomere length was not associated with diabetes duration or glucose control based on an hemoglobin A1c <7 or <8 % (all p > 0.05). CONCLUSIONS: In this study of the US general population, leukocyte telomere length was not associated with diabetes status, diabetes duration, or diabetes control.
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spelling pubmed-45891932015-10-01 Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey Menke, Andy Casagrande, Sarah Cowie, Catherine C. BMC Endocr Disord Research Article BACKGROUND: Studies investigating the association between telomere length and diabetes have been inconsistent, and there are few data available investigating the associations of telomere length with diabetes duration and control. We evaluated the relationship of leukocyte telomere length with diabetes, and the relationship of leukocyte telomere length with diabetes duration and poor glucose control among people with diabetes. METHODS: We used data from the 1999–2002 National Health and Nutrition Examination Survey, a representative sample of the US civilian non-institutionalized population. In 3921 participants, leukocyte telomere length was measured and diabetes status was determined based on a previous diagnosis, hemoglobin A1c ≥6.5 %, or fasting glucose ≥126 mg/dL. RESULTS: The odds ratios (95 % confidence intervals) of diabetes associated with the first, second, and third quartile of leukocyte telomere length, compared to the highest quartile, was 2.09 (1.46–2.98), 1.74 (1.30–2.31), and 1.08 (0.76–1.54), respectively (p-trend < 0.01), in unadjusted models and 0.74 (0.48–1.14), 0.91 (0.61–1.34), and 0.87 (0.59–1.29), respectively (p-trend = 0.20), in multivariable adjusted models. Among participants with diabetes, unadjusted and adjusted leukocyte telomere length was not associated with diabetes duration or glucose control based on an hemoglobin A1c <7 or <8 % (all p > 0.05). CONCLUSIONS: In this study of the US general population, leukocyte telomere length was not associated with diabetes status, diabetes duration, or diabetes control. BioMed Central 2015-09-29 /pmc/articles/PMC4589193/ /pubmed/26419237 http://dx.doi.org/10.1186/s12902-015-0050-1 Text en © Menke et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Menke, Andy
Casagrande, Sarah
Cowie, Catherine C.
Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey
title Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey
title_full Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey
title_fullStr Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey
title_full_unstemmed Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey
title_short Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey
title_sort leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 national health and nutrition examination survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589193/
https://www.ncbi.nlm.nih.gov/pubmed/26419237
http://dx.doi.org/10.1186/s12902-015-0050-1
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