Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

The identification of small molecules that target specific CFTR variants has ushered in a new era of treatment for cystic fibrosis (CF), yet optimal, individualized treatment of CF will require identification and targeting of disease modifiers. Here we use genome-wide association analysis to identif...

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Detalles Bibliográficos
Autores principales: Corvol, Harriet, Blackman, Scott M., Boëlle, Pierre-Yves, Gallins, Paul J., Pace, Rhonda G., Stonebraker, Jaclyn R., Accurso, Frank J., Clement, Annick, Collaco, Joseph M., Dang, Hong, Dang, Anthony T., Franca, Arianna, Gong, Jiafen, Guillot, Loic, Keenan, Katherine, Li, Weili, Lin, Fan, Patrone, Michael V., Raraigh, Karen S., Sun, Lei, Zhou, Yi-Hui, O'Neal, Wanda K., Sontag, Marci K., Levy, Hara, Durie, Peter R., Rommens, Johanna M., Drumm, Mitchell L., Wright, Fred A., Strug, Lisa J., Cutting, Garry R., Knowles, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589222/
https://www.ncbi.nlm.nih.gov/pubmed/26417704
http://dx.doi.org/10.1038/ncomms9382

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