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Nasal Administration of Cholera Toxin as a Mucosal Adjuvant Damages the Olfactory System in Mice

Cholera toxin (CT) induces severe diarrhea in humans but acts as an adjuvant to enhance immune responses to vaccines when administered orally. Nasally administered CT also acts as an adjuvant, but CT and CT derivatives, including the B subunit of CT (CTB), are taken up from the olfactory epithelium...

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Detalles Bibliográficos
Autores principales:	Fukuyama, Yoshiko, Okada, Kazunari, Yamaguchi, Masahiro, Kiyono, Hiroshi, Mori, Kensaku, Yuki, Yoshikazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589288/ https://www.ncbi.nlm.nih.gov/pubmed/26422280 http://dx.doi.org/10.1371/journal.pone.0139368

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