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Endocytosed β2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils

Dialysis-related amyloidosis is a major complication in long-term hemodialysis patients. In dialysis-related amyloidosis, β2-microglobulin (β2-m) amyloid fibrils deposit in the osteoarticular tissue, leading to carpal tunnel syndrome and destructive arthropathy with cystic bone lesions, but the mech...

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Detalles Bibliográficos
Autores principales:	Okoshi, Tadakazu, Yamaguchi, Itaru, Ozawa, Daisaku, Hasegawa, Kazuhiro, Naiki, Hironobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589361/ https://www.ncbi.nlm.nih.gov/pubmed/26421922 http://dx.doi.org/10.1371/journal.pone.0139330

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