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Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial
PURPOSE: Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [(18)F]HX4 in patients with head and neck and lung cancer. METHODS: Nine patients with lung cancer and ten with head an...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589564/ https://www.ncbi.nlm.nih.gov/pubmed/26136164 http://dx.doi.org/10.1007/s00259-015-3100-z |
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author | Zegers, Catharina M. L. van Elmpt, Wouter Szardenings, Katrin Kolb, Hartmuth Waxman, Alan Subramaniam, Rathan M. Moon, Dae Hyuk Brunetti, Jacqueline C. Srinivas, Shyam M. Lambin, Philippe Chien, David |
author_facet | Zegers, Catharina M. L. van Elmpt, Wouter Szardenings, Katrin Kolb, Hartmuth Waxman, Alan Subramaniam, Rathan M. Moon, Dae Hyuk Brunetti, Jacqueline C. Srinivas, Shyam M. Lambin, Philippe Chien, David |
author_sort | Zegers, Catharina M. L. |
collection | PubMed |
description | PURPOSE: Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [(18)F]HX4 in patients with head and neck and lung cancer. METHODS: Nine patients with lung cancer and ten with head and neck cancer were included in the analysis (NCT01075399). Two sequential pretreatment [(18)F]HX4 PET/CT scans were acquired within 1 week. The maximal and mean standardized uptake values (SUV(max) and SUV(mean)) were defined and the tumor-to-background ratios (TBR) were calculated. In addition, hypoxic volumes were determined as the volume of the tumor with a TBR >1.2 (HV(1.2)). Bland Altman analysis of the uptake parameters was performed and coefficients of repeatability were calculated. To evaluate the spatial repeatability of the uptake, the PET/CT images were registered and a voxel-wise comparison of the uptake was performed, providing a correlation coefficient. RESULTS: All parameters of [(18)F]HX4 uptake were significantly correlated between scans: SUV(max) (r = 0.958, p < 0.001), SUV(mean) (r = 0.946, p < 0.001), TBR(max) (r = 0.962, p < 0.001) and HV(1.2) (r = 0.995, p < 0.001). The relative coefficients of repeatability were 15 % (SUV(mean)), 17 % (SUV(max)) and 17 % (TBR(max)). Voxel-wise analysis of the spatial uptake pattern within the tumors provided an average correlation of 0.65 ± 0.14. CONCLUSION: Repeated hypoxia PET scans with [(18)F]HX4 provide reproducible and spatially stable results in patients with head and neck cancer and patients with lung cancer. [(18)F]HX4 PET imaging can be used to assess the hypoxic status of tumors and has the potential to aid hypoxia-targeted treatments. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00259-015-3100-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4589564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-45895642015-10-06 Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial Zegers, Catharina M. L. van Elmpt, Wouter Szardenings, Katrin Kolb, Hartmuth Waxman, Alan Subramaniam, Rathan M. Moon, Dae Hyuk Brunetti, Jacqueline C. Srinivas, Shyam M. Lambin, Philippe Chien, David Eur J Nucl Med Mol Imaging Original Article PURPOSE: Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [(18)F]HX4 in patients with head and neck and lung cancer. METHODS: Nine patients with lung cancer and ten with head and neck cancer were included in the analysis (NCT01075399). Two sequential pretreatment [(18)F]HX4 PET/CT scans were acquired within 1 week. The maximal and mean standardized uptake values (SUV(max) and SUV(mean)) were defined and the tumor-to-background ratios (TBR) were calculated. In addition, hypoxic volumes were determined as the volume of the tumor with a TBR >1.2 (HV(1.2)). Bland Altman analysis of the uptake parameters was performed and coefficients of repeatability were calculated. To evaluate the spatial repeatability of the uptake, the PET/CT images were registered and a voxel-wise comparison of the uptake was performed, providing a correlation coefficient. RESULTS: All parameters of [(18)F]HX4 uptake were significantly correlated between scans: SUV(max) (r = 0.958, p < 0.001), SUV(mean) (r = 0.946, p < 0.001), TBR(max) (r = 0.962, p < 0.001) and HV(1.2) (r = 0.995, p < 0.001). The relative coefficients of repeatability were 15 % (SUV(mean)), 17 % (SUV(max)) and 17 % (TBR(max)). Voxel-wise analysis of the spatial uptake pattern within the tumors provided an average correlation of 0.65 ± 0.14. CONCLUSION: Repeated hypoxia PET scans with [(18)F]HX4 provide reproducible and spatially stable results in patients with head and neck cancer and patients with lung cancer. [(18)F]HX4 PET imaging can be used to assess the hypoxic status of tumors and has the potential to aid hypoxia-targeted treatments. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00259-015-3100-z) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-07-02 2015 /pmc/articles/PMC4589564/ /pubmed/26136164 http://dx.doi.org/10.1007/s00259-015-3100-z Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Zegers, Catharina M. L. van Elmpt, Wouter Szardenings, Katrin Kolb, Hartmuth Waxman, Alan Subramaniam, Rathan M. Moon, Dae Hyuk Brunetti, Jacqueline C. Srinivas, Shyam M. Lambin, Philippe Chien, David Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial |
title | Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial |
title_full | Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial |
title_fullStr | Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial |
title_full_unstemmed | Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial |
title_short | Repeatability of hypoxia PET imaging using [(18)F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial |
title_sort | repeatability of hypoxia pet imaging using [(18)f]hx4 in lung and head and neck cancer patients: a prospective multicenter trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589564/ https://www.ncbi.nlm.nih.gov/pubmed/26136164 http://dx.doi.org/10.1007/s00259-015-3100-z |
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