Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient

Q fever is an uncommon but likely underreported zoonotic infection. Severe hyperferritinemia has been associated with hemophagocytic lymphohistiocytosis and other infectious diseases. In this study, we report a case of Coxiella burnetii infection in an asplenic patient complicated by severe hyperfer...

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Autores principales: Paine, Allison, Miya, Tadashi, Webb, Brandon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589646/
https://www.ncbi.nlm.nih.gov/pubmed/26430699
http://dx.doi.org/10.1093/ofid/ofv125
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author Paine, Allison
Miya, Tadashi
Webb, Brandon J.
author_facet Paine, Allison
Miya, Tadashi
Webb, Brandon J.
author_sort Paine, Allison
collection PubMed
description Q fever is an uncommon but likely underreported zoonotic infection. Severe hyperferritinemia has been associated with hemophagocytic lymphohistiocytosis and other infectious diseases. In this study, we report a case of Coxiella burnetii infection in an asplenic patient complicated by severe hyperferritinemia and bone marrow infiltration. In this case, the marked ferritin elevation may have been an indicator of profound systemic macrophage activation due to preferential intracellular infection of this cell type by C burnetii, perhaps exacerbated by altered mononuclear phagocyte system function in the setting of asplenia.
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spelling pubmed-45896462015-10-01 Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient Paine, Allison Miya, Tadashi Webb, Brandon J. Open Forum Infect Dis Brief Reports Q fever is an uncommon but likely underreported zoonotic infection. Severe hyperferritinemia has been associated with hemophagocytic lymphohistiocytosis and other infectious diseases. In this study, we report a case of Coxiella burnetii infection in an asplenic patient complicated by severe hyperferritinemia and bone marrow infiltration. In this case, the marked ferritin elevation may have been an indicator of profound systemic macrophage activation due to preferential intracellular infection of this cell type by C burnetii, perhaps exacerbated by altered mononuclear phagocyte system function in the setting of asplenia. Oxford University Press 2015-08-26 /pmc/articles/PMC4589646/ /pubmed/26430699 http://dx.doi.org/10.1093/ofid/ofv125 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Paine, Allison
Miya, Tadashi
Webb, Brandon J.
Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient
title Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient
title_full Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient
title_fullStr Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient
title_full_unstemmed Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient
title_short Coxiella burnetii Infection With Severe Hyperferritinemia in an Asplenic Patient
title_sort coxiella burnetii infection with severe hyperferritinemia in an asplenic patient
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589646/
https://www.ncbi.nlm.nih.gov/pubmed/26430699
http://dx.doi.org/10.1093/ofid/ofv125
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