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Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study

The mechanisms through which genes influence body weight are not well understood, but appetite has been implicated as one mediating pathway. Here we use data from two independent population-based Finnish cohorts (4632 adults aged 25–74 years from the DILGOM study and 1231 twin individuals aged 21–26...

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Autores principales: Konttinen, Hanna, Llewellyn, Clare, Wardle, Jane, Silventoinen, Karri, Joensuu, Anni, Männistö, Satu, Salomaa, Veikko, Jousilahti, Pekka, Kaprio, Jaakko, Perola, Markus, Haukkala, Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589697/
https://www.ncbi.nlm.nih.gov/pubmed/26423639
http://dx.doi.org/10.1038/srep14726
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author Konttinen, Hanna
Llewellyn, Clare
Wardle, Jane
Silventoinen, Karri
Joensuu, Anni
Männistö, Satu
Salomaa, Veikko
Jousilahti, Pekka
Kaprio, Jaakko
Perola, Markus
Haukkala, Ari
author_facet Konttinen, Hanna
Llewellyn, Clare
Wardle, Jane
Silventoinen, Karri
Joensuu, Anni
Männistö, Satu
Salomaa, Veikko
Jousilahti, Pekka
Kaprio, Jaakko
Perola, Markus
Haukkala, Ari
author_sort Konttinen, Hanna
collection PubMed
description The mechanisms through which genes influence body weight are not well understood, but appetite has been implicated as one mediating pathway. Here we use data from two independent population-based Finnish cohorts (4632 adults aged 25–74 years from the DILGOM study and 1231 twin individuals aged 21–26 years from the FinnTwin12 study) to investigate whether two appetitive traits mediate the associations between known obesity-related genetic variants and adiposity. The results from structural equation modelling indicate that the effects of a polygenic risk score (90 obesity-related loci) on measured body mass index and waist circumference are partly mediated through higher levels of uncontrolled eating (β(indirect )= 0.030–0.032, P < 0.001 in DILGOM) and emotional eating (β(indirect )= 0.020–0.022, P < 0.001 in DILGOM and β(indirect )= 0.013–0.015, P = 0.043–0.044 in FinnTwin12). Our findings suggest that genetic predispositions to obesity may partly exert their effects through appetitive traits reflecting lack of control over eating or eating in response to negative emotions. Obesity prevention and treatment studies should examine the impact of targeting these eating behaviours, especially among individuals having a high genetic predisposition to obesity.
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spelling pubmed-45896972015-10-13 Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study Konttinen, Hanna Llewellyn, Clare Wardle, Jane Silventoinen, Karri Joensuu, Anni Männistö, Satu Salomaa, Veikko Jousilahti, Pekka Kaprio, Jaakko Perola, Markus Haukkala, Ari Sci Rep Article The mechanisms through which genes influence body weight are not well understood, but appetite has been implicated as one mediating pathway. Here we use data from two independent population-based Finnish cohorts (4632 adults aged 25–74 years from the DILGOM study and 1231 twin individuals aged 21–26 years from the FinnTwin12 study) to investigate whether two appetitive traits mediate the associations between known obesity-related genetic variants and adiposity. The results from structural equation modelling indicate that the effects of a polygenic risk score (90 obesity-related loci) on measured body mass index and waist circumference are partly mediated through higher levels of uncontrolled eating (β(indirect )= 0.030–0.032, P < 0.001 in DILGOM) and emotional eating (β(indirect )= 0.020–0.022, P < 0.001 in DILGOM and β(indirect )= 0.013–0.015, P = 0.043–0.044 in FinnTwin12). Our findings suggest that genetic predispositions to obesity may partly exert their effects through appetitive traits reflecting lack of control over eating or eating in response to negative emotions. Obesity prevention and treatment studies should examine the impact of targeting these eating behaviours, especially among individuals having a high genetic predisposition to obesity. Nature Publishing Group 2015-10-01 /pmc/articles/PMC4589697/ /pubmed/26423639 http://dx.doi.org/10.1038/srep14726 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Konttinen, Hanna
Llewellyn, Clare
Wardle, Jane
Silventoinen, Karri
Joensuu, Anni
Männistö, Satu
Salomaa, Veikko
Jousilahti, Pekka
Kaprio, Jaakko
Perola, Markus
Haukkala, Ari
Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
title Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
title_full Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
title_fullStr Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
title_full_unstemmed Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
title_short Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
title_sort appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589697/
https://www.ncbi.nlm.nih.gov/pubmed/26423639
http://dx.doi.org/10.1038/srep14726
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