JBP485 promotes corneal epithelial wound healing

Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In...

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Autores principales: Nagata, Maho, Nakamura, Takahiro, Hata, Yuiko, Yamaguchi, Shumpei, Kaku, Taiichi, Kinoshita, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589775/
https://www.ncbi.nlm.nih.gov/pubmed/26424376
http://dx.doi.org/10.1038/srep14776
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author Nagata, Maho
Nakamura, Takahiro
Hata, Yuiko
Yamaguchi, Shumpei
Kaku, Taiichi
Kinoshita, Shigeru
author_facet Nagata, Maho
Nakamura, Takahiro
Hata, Yuiko
Yamaguchi, Shumpei
Kaku, Taiichi
Kinoshita, Shigeru
author_sort Nagata, Maho
collection PubMed
description Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased the proliferation and migration of corneal epithelial cells (CECs). Moreover, JBP485 accelerated corneal epithelial wound healing in vivo without inflammation and neovascularization and was found to be effective for the treatment of corneal damage. These data indicate that JBP485 efficiently activates the viability of CECs and has potential as a novel treatment for various kinds of corneal epithelial disease.
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spelling pubmed-45897752015-10-13 JBP485 promotes corneal epithelial wound healing Nagata, Maho Nakamura, Takahiro Hata, Yuiko Yamaguchi, Shumpei Kaku, Taiichi Kinoshita, Shigeru Sci Rep Article Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, further novel treatments are needed to improve clinical outcomes for this type of disease. In the present study, it was found that placental extract-derived dipeptide (JBP485) significantly increased the proliferation and migration of corneal epithelial cells (CECs). Moreover, JBP485 accelerated corneal epithelial wound healing in vivo without inflammation and neovascularization and was found to be effective for the treatment of corneal damage. These data indicate that JBP485 efficiently activates the viability of CECs and has potential as a novel treatment for various kinds of corneal epithelial disease. Nature Publishing Group 2015-10-01 /pmc/articles/PMC4589775/ /pubmed/26424376 http://dx.doi.org/10.1038/srep14776 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Nagata, Maho
Nakamura, Takahiro
Hata, Yuiko
Yamaguchi, Shumpei
Kaku, Taiichi
Kinoshita, Shigeru
JBP485 promotes corneal epithelial wound healing
title JBP485 promotes corneal epithelial wound healing
title_full JBP485 promotes corneal epithelial wound healing
title_fullStr JBP485 promotes corneal epithelial wound healing
title_full_unstemmed JBP485 promotes corneal epithelial wound healing
title_short JBP485 promotes corneal epithelial wound healing
title_sort jbp485 promotes corneal epithelial wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589775/
https://www.ncbi.nlm.nih.gov/pubmed/26424376
http://dx.doi.org/10.1038/srep14776
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