The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1

Cyclin-dependent kinase 1 (Cdk1) is absolutely essential for cell division. Complete ablation of Cdk1 precludes the entry of G2 phase cells into mitosis, and is early embryonic lethal in mice. Dampening Cdk1 activation, by reducing gene expression or upon treatment with cell-permeable Cdk1 inhibitor...

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Detalles Bibliográficos
Autores principales: Voets, Erik, Marsman, Judith, Demmers, Jeroen, Beijersbergen, Roderick, Wolthuis, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589785/
https://www.ncbi.nlm.nih.gov/pubmed/26423135
http://dx.doi.org/10.1038/srep14798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589785/
https://www.ncbi.nlm.nih.gov/pubmed/26423135
http://dx.doi.org/10.1038/srep14798

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