Guided extracellular matrix formation from fibroblast cells cultured on bio-inspired configurable multiscale substrata

Engineering complex extracellular matrix (ECM) is an important challenge for cell and tissue engineering applications as well as for understanding fundamental cell biology. We developed the methodology for fabrication of precisely controllable multiscale hierarchical structures using capillary force...

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Detalles Bibliográficos
Autores principales: Bae, Won-Gyu, Kim, Jangho, Choung, Yun-Hoon, Chung, Yesol, Suh, Kahp Y., Pang, Changhyun, Chung, Jong Hoon, Jeong, Hoon Eui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589828/
https://www.ncbi.nlm.nih.gov/pubmed/26543882
http://dx.doi.org/10.1016/j.dib.2015.08.021
Descripción
Sumario:Engineering complex extracellular matrix (ECM) is an important challenge for cell and tissue engineering applications as well as for understanding fundamental cell biology. We developed the methodology for fabrication of precisely controllable multiscale hierarchical structures using capillary force lithography in combination with original wrinkling technique for the generation of well-defined native ECM-like platforms by culturing fibroblast cells on the multiscale substrata [1]. This paper provides information on detailed characteristics of polyethylene glycol-diacrylate multiscale substrata. In addition, a possible model for guided extracellular matrix formation from fibroblast cells cultured on bio-inspired configurable multiscale substrata is proposed.

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