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Measuring longitudinal myelin water fraction in new multiple sclerosis lesions

OBJECTIVES: Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF), an MRI biomarker of myelin, in new MS lesions and...

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Autores principales: Vargas, Wendy S., Monohan, Elizabeth, Pandya, Sneha, Raj, Ashish, Vartanian, Timothy, Nguyen, Thanh D., Hurtado Rúa, Sandra M., Gauthier, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589846/
https://www.ncbi.nlm.nih.gov/pubmed/26594620
http://dx.doi.org/10.1016/j.nicl.2015.09.003
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author Vargas, Wendy S.
Monohan, Elizabeth
Pandya, Sneha
Raj, Ashish
Vartanian, Timothy
Nguyen, Thanh D.
Hurtado Rúa, Sandra M.
Gauthier, Susan A.
author_facet Vargas, Wendy S.
Monohan, Elizabeth
Pandya, Sneha
Raj, Ashish
Vartanian, Timothy
Nguyen, Thanh D.
Hurtado Rúa, Sandra M.
Gauthier, Susan A.
author_sort Vargas, Wendy S.
collection PubMed
description OBJECTIVES: Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF), an MRI biomarker of myelin, in new MS lesions and to identify factors that influence their subsequent myelin content. METHODS: Twenty-three MS patients were scanned with whole-brain Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) MWF mapping at baseline and median follow-up of 6 months. Eleven healthy controls (HC) confirmed the reproducibility of FAST-T2 in white matter regions of interests (ROIs) similar to a lesion size. A random-effect-model was implemented to determine the association between baseline clinical and lesion variables and the subsequent MWF. RESULTS: ROI-based measurements in HCs were highly correlated between scans [mean r = 0.893 (.764–.967)]. In MS patients, 38 gadolinium enhancing (Gd+) and 25 new non-enhancing (Gd−) T2 hyperintense lesions (5.7 months, ±3.8) were identified. Significant improvement in MWF was seen in Gd+ lesions (0.035 ± 0.029, p < 0.001) as compared to Gd− lesions (0.006 ± 0.017, p = 0.065). In the model, a higher baseline MWF (p < 0.001) and the presence of Gd (p < 0.001) were associated with higher subsequent MWF. CONCLUSIONS: FAST T2 provides a clinically feasible method to quantify MWF in new MS lesions. The observed influence of baseline MWF, which represents a combined effect of both resolving edema and myelin change within acute lesions, suggests that the extent of initial inflammation impacts final myelin recovery.
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spelling pubmed-45898462015-11-20 Measuring longitudinal myelin water fraction in new multiple sclerosis lesions Vargas, Wendy S. Monohan, Elizabeth Pandya, Sneha Raj, Ashish Vartanian, Timothy Nguyen, Thanh D. Hurtado Rúa, Sandra M. Gauthier, Susan A. Neuroimage Clin Regular Article OBJECTIVES: Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF), an MRI biomarker of myelin, in new MS lesions and to identify factors that influence their subsequent myelin content. METHODS: Twenty-three MS patients were scanned with whole-brain Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) MWF mapping at baseline and median follow-up of 6 months. Eleven healthy controls (HC) confirmed the reproducibility of FAST-T2 in white matter regions of interests (ROIs) similar to a lesion size. A random-effect-model was implemented to determine the association between baseline clinical and lesion variables and the subsequent MWF. RESULTS: ROI-based measurements in HCs were highly correlated between scans [mean r = 0.893 (.764–.967)]. In MS patients, 38 gadolinium enhancing (Gd+) and 25 new non-enhancing (Gd−) T2 hyperintense lesions (5.7 months, ±3.8) were identified. Significant improvement in MWF was seen in Gd+ lesions (0.035 ± 0.029, p < 0.001) as compared to Gd− lesions (0.006 ± 0.017, p = 0.065). In the model, a higher baseline MWF (p < 0.001) and the presence of Gd (p < 0.001) were associated with higher subsequent MWF. CONCLUSIONS: FAST T2 provides a clinically feasible method to quantify MWF in new MS lesions. The observed influence of baseline MWF, which represents a combined effect of both resolving edema and myelin change within acute lesions, suggests that the extent of initial inflammation impacts final myelin recovery. Elsevier 2015-09-12 /pmc/articles/PMC4589846/ /pubmed/26594620 http://dx.doi.org/10.1016/j.nicl.2015.09.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Vargas, Wendy S.
Monohan, Elizabeth
Pandya, Sneha
Raj, Ashish
Vartanian, Timothy
Nguyen, Thanh D.
Hurtado Rúa, Sandra M.
Gauthier, Susan A.
Measuring longitudinal myelin water fraction in new multiple sclerosis lesions
title Measuring longitudinal myelin water fraction in new multiple sclerosis lesions
title_full Measuring longitudinal myelin water fraction in new multiple sclerosis lesions
title_fullStr Measuring longitudinal myelin water fraction in new multiple sclerosis lesions
title_full_unstemmed Measuring longitudinal myelin water fraction in new multiple sclerosis lesions
title_short Measuring longitudinal myelin water fraction in new multiple sclerosis lesions
title_sort measuring longitudinal myelin water fraction in new multiple sclerosis lesions
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589846/
https://www.ncbi.nlm.nih.gov/pubmed/26594620
http://dx.doi.org/10.1016/j.nicl.2015.09.003
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