RELEVANCE OF TNF-α IN THE CONTEXT OF OTHER INFLAMMATORY CYTOKINES IN THE PROGRESSION OF DIABETIC NEPHROPATHY

An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical “micro-inflammation” with influx of macrophages and consequential generation of myriad pro-inflammatory cytokines and ensuing kidney damage. Among various pro-inflammatory cytokines TNF-α has attracted the most attention since it amplifies the inflammatory network of cytokines leading to worsening of the progression of diabetic nephropathy. The accompanying article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.