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A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of 185 thousand CAD cases and controls...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589895/ https://www.ncbi.nlm.nih.gov/pubmed/26343387 http://dx.doi.org/10.1038/ng.3396 |
| _version_ | 1782392863803310080 |
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| author | Nikpay, Majid Goel, Anuj Won, Hong-Hee Hall, Leanne M Willenborg, Christina Kanoni, Stavroula Saleheen, Danish Kyriakou, Theodosios Nelson, Christopher P Hopewell, Jemma C Webb, Thomas R Zeng, Lingyao Dehghan, Abbas Alver, Maris Armasu, Sebastian M Auro, Kirsi Bjonnes, Andrew Chasman, Daniel I Chen, Shufeng Ford, Ian Franceschini, Nora Gieger, Christian Grace, Christopher Gustafsson, Stefan Huang, Jie Hwang, Shih-Jen Kim, Yun Kyoung Kleber, Marcus E Lau, King Wai Lu, Xiangfeng Lu, Yingchang Lyytikäinen, Leo-Pekka Mihailov, Evelin Morrison, Alanna C Pervjakova, Natalia Qu, Liming Rose, Lynda M Salfati, Elias Saxena, Richa Scholz, Markus Smith, Albert V Tikkanen, Emmi Uitterlinden, Andre Yang, Xueli Zhang, Weihua Zhao, Wei de Andrade, Mariza de Vries, Paul S van Zuydam, Natalie R Anand, Sonia S Bertram, Lars Beutner, Frank Dedoussis, George Frossard, Philippe Gauguier, Dominique Goodall, Alison H Gottesman, Omri Haber, Marc Han, Bok-Ghee Huang, Jianfeng Jalilzadeh, Shapour Kessler, Thorsten König, Inke R Lannfelt, Lars Lieb, Wolfgang Lind, Lars Lindgren, Cecilia M Lokki, Marja-Liisa Magnusson, Patrik K Mallick, Nadeem H Mehra, Narinder Meitinger, Thomas Memon, Fazal-ur-Rehman Morris, Andrew P Nieminen, Markku S Pedersen, Nancy L Peters, Annette Rallidis, Loukianos S Rasheed, Asif Samuel, Maria Shah, Svati H Sinisalo, Juha Stirrups, Kathleen E Trompet, Stella Wang, Laiyuan Zaman, Khan S Ardissino, Diego Boerwinkle, Eric Borecki, Ingrid B Bottinger, Erwin P Buring, Julie E Chambers, John C Collins, Rory Cupples, L Adrienne Danesh, John Demuth, Ilja Elosua, Roberto Epstein, Stephen E Esko, Tõnu Feitosa, Mary F Franco, Oscar H Franzosi, Maria Grazia Granger, Christopher B Gu, Dongfeng Gudnason, Vilmundur Hall, Alistair S Hamsten, Anders Harris, Tamara B Hazen, Stanley L Hengstenberg, Christian Hofman, Albert Ingelsson, Erik Iribarren, Carlos Jukema, J Wouter Karhunen, Pekka J Kim, Bong-Jo Kooner, Jaspal S Kullo, Iftikhar J Lehtimäki, Terho Loos, Ruth J F Melander, Olle Metspalu, Andres März, Winfried Palmer, Colin N Perola, Markus Quertermous, Thomas Rader, Daniel J Ridker, Paul M Ripatti, Samuli Roberts, Robert Salomaa, Veikko Sanghera, Dharambir K Schwartz, Stephen M Seedorf, Udo Stewart, Alexandre F Stott, David J Thiery, Joachim Zalloua, Pierre A O’Donnell, Christopher J Reilly, Muredach P Assimes, Themistocles L Thompson, John R Erdmann, Jeanette Clarke, Robert Watkins, Hugh Kathiresan, Sekar McPherson, Ruth Deloukas, Panos Schunkert, Heribert Samani, Nilesh J Farrall, Martin |
| author_facet | Nikpay, Majid Goel, Anuj Won, Hong-Hee Hall, Leanne M Willenborg, Christina Kanoni, Stavroula Saleheen, Danish Kyriakou, Theodosios Nelson, Christopher P Hopewell, Jemma C Webb, Thomas R Zeng, Lingyao Dehghan, Abbas Alver, Maris Armasu, Sebastian M Auro, Kirsi Bjonnes, Andrew Chasman, Daniel I Chen, Shufeng Ford, Ian Franceschini, Nora Gieger, Christian Grace, Christopher Gustafsson, Stefan Huang, Jie Hwang, Shih-Jen Kim, Yun Kyoung Kleber, Marcus E Lau, King Wai Lu, Xiangfeng Lu, Yingchang Lyytikäinen, Leo-Pekka Mihailov, Evelin Morrison, Alanna C Pervjakova, Natalia Qu, Liming Rose, Lynda M Salfati, Elias Saxena, Richa Scholz, Markus Smith, Albert V Tikkanen, Emmi Uitterlinden, Andre Yang, Xueli Zhang, Weihua Zhao, Wei de Andrade, Mariza de Vries, Paul S van Zuydam, Natalie R Anand, Sonia S Bertram, Lars Beutner, Frank Dedoussis, George Frossard, Philippe Gauguier, Dominique Goodall, Alison H Gottesman, Omri Haber, Marc Han, Bok-Ghee Huang, Jianfeng Jalilzadeh, Shapour Kessler, Thorsten König, Inke R Lannfelt, Lars Lieb, Wolfgang Lind, Lars Lindgren, Cecilia M Lokki, Marja-Liisa Magnusson, Patrik K Mallick, Nadeem H Mehra, Narinder Meitinger, Thomas Memon, Fazal-ur-Rehman Morris, Andrew P Nieminen, Markku S Pedersen, Nancy L Peters, Annette Rallidis, Loukianos S Rasheed, Asif Samuel, Maria Shah, Svati H Sinisalo, Juha Stirrups, Kathleen E Trompet, Stella Wang, Laiyuan Zaman, Khan S Ardissino, Diego Boerwinkle, Eric Borecki, Ingrid B Bottinger, Erwin P Buring, Julie E Chambers, John C Collins, Rory Cupples, L Adrienne Danesh, John Demuth, Ilja Elosua, Roberto Epstein, Stephen E Esko, Tõnu Feitosa, Mary F Franco, Oscar H Franzosi, Maria Grazia Granger, Christopher B Gu, Dongfeng Gudnason, Vilmundur Hall, Alistair S Hamsten, Anders Harris, Tamara B Hazen, Stanley L Hengstenberg, Christian Hofman, Albert Ingelsson, Erik Iribarren, Carlos Jukema, J Wouter Karhunen, Pekka J Kim, Bong-Jo Kooner, Jaspal S Kullo, Iftikhar J Lehtimäki, Terho Loos, Ruth J F Melander, Olle Metspalu, Andres März, Winfried Palmer, Colin N Perola, Markus Quertermous, Thomas Rader, Daniel J Ridker, Paul M Ripatti, Samuli Roberts, Robert Salomaa, Veikko Sanghera, Dharambir K Schwartz, Stephen M Seedorf, Udo Stewart, Alexandre F Stott, David J Thiery, Joachim Zalloua, Pierre A O’Donnell, Christopher J Reilly, Muredach P Assimes, Themistocles L Thompson, John R Erdmann, Jeanette Clarke, Robert Watkins, Hugh Kathiresan, Sekar McPherson, Ruth Deloukas, Panos Schunkert, Heribert Samani, Nilesh J Farrall, Martin |
| author_sort | Nikpay, Majid |
| collection | PubMed |
| description | Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of 185 thousand CAD cases and controls, interrogating 6.7 million common (MAF>0.05) as well as 2.7 million low frequency (0.005<MAF<0.05) variants. In addition to confirmation of most known CAD loci, we identified 10 novel loci, eight additive and two recessive, that contain candidate genes that newly implicate biological processes in vessel walls. We observed intra-locus allelic heterogeneity but little evidence of low frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size. |
| format | Online Article Text |
| id | pubmed-4589895 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-45898952016-04-01 A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease Nikpay, Majid Goel, Anuj Won, Hong-Hee Hall, Leanne M Willenborg, Christina Kanoni, Stavroula Saleheen, Danish Kyriakou, Theodosios Nelson, Christopher P Hopewell, Jemma C Webb, Thomas R Zeng, Lingyao Dehghan, Abbas Alver, Maris Armasu, Sebastian M Auro, Kirsi Bjonnes, Andrew Chasman, Daniel I Chen, Shufeng Ford, Ian Franceschini, Nora Gieger, Christian Grace, Christopher Gustafsson, Stefan Huang, Jie Hwang, Shih-Jen Kim, Yun Kyoung Kleber, Marcus E Lau, King Wai Lu, Xiangfeng Lu, Yingchang Lyytikäinen, Leo-Pekka Mihailov, Evelin Morrison, Alanna C Pervjakova, Natalia Qu, Liming Rose, Lynda M Salfati, Elias Saxena, Richa Scholz, Markus Smith, Albert V Tikkanen, Emmi Uitterlinden, Andre Yang, Xueli Zhang, Weihua Zhao, Wei de Andrade, Mariza de Vries, Paul S van Zuydam, Natalie R Anand, Sonia S Bertram, Lars Beutner, Frank Dedoussis, George Frossard, Philippe Gauguier, Dominique Goodall, Alison H Gottesman, Omri Haber, Marc Han, Bok-Ghee Huang, Jianfeng Jalilzadeh, Shapour Kessler, Thorsten König, Inke R Lannfelt, Lars Lieb, Wolfgang Lind, Lars Lindgren, Cecilia M Lokki, Marja-Liisa Magnusson, Patrik K Mallick, Nadeem H Mehra, Narinder Meitinger, Thomas Memon, Fazal-ur-Rehman Morris, Andrew P Nieminen, Markku S Pedersen, Nancy L Peters, Annette Rallidis, Loukianos S Rasheed, Asif Samuel, Maria Shah, Svati H Sinisalo, Juha Stirrups, Kathleen E Trompet, Stella Wang, Laiyuan Zaman, Khan S Ardissino, Diego Boerwinkle, Eric Borecki, Ingrid B Bottinger, Erwin P Buring, Julie E Chambers, John C Collins, Rory Cupples, L Adrienne Danesh, John Demuth, Ilja Elosua, Roberto Epstein, Stephen E Esko, Tõnu Feitosa, Mary F Franco, Oscar H Franzosi, Maria Grazia Granger, Christopher B Gu, Dongfeng Gudnason, Vilmundur Hall, Alistair S Hamsten, Anders Harris, Tamara B Hazen, Stanley L Hengstenberg, Christian Hofman, Albert Ingelsson, Erik Iribarren, Carlos Jukema, J Wouter Karhunen, Pekka J Kim, Bong-Jo Kooner, Jaspal S Kullo, Iftikhar J Lehtimäki, Terho Loos, Ruth J F Melander, Olle Metspalu, Andres März, Winfried Palmer, Colin N Perola, Markus Quertermous, Thomas Rader, Daniel J Ridker, Paul M Ripatti, Samuli Roberts, Robert Salomaa, Veikko Sanghera, Dharambir K Schwartz, Stephen M Seedorf, Udo Stewart, Alexandre F Stott, David J Thiery, Joachim Zalloua, Pierre A O’Donnell, Christopher J Reilly, Muredach P Assimes, Themistocles L Thompson, John R Erdmann, Jeanette Clarke, Robert Watkins, Hugh Kathiresan, Sekar McPherson, Ruth Deloukas, Panos Schunkert, Heribert Samani, Nilesh J Farrall, Martin Nat Genet Article Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of 185 thousand CAD cases and controls, interrogating 6.7 million common (MAF>0.05) as well as 2.7 million low frequency (0.005<MAF<0.05) variants. In addition to confirmation of most known CAD loci, we identified 10 novel loci, eight additive and two recessive, that contain candidate genes that newly implicate biological processes in vessel walls. We observed intra-locus allelic heterogeneity but little evidence of low frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size. 2015-09-07 2015-10 /pmc/articles/PMC4589895/ /pubmed/26343387 http://dx.doi.org/10.1038/ng.3396 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Nikpay, Majid Goel, Anuj Won, Hong-Hee Hall, Leanne M Willenborg, Christina Kanoni, Stavroula Saleheen, Danish Kyriakou, Theodosios Nelson, Christopher P Hopewell, Jemma C Webb, Thomas R Zeng, Lingyao Dehghan, Abbas Alver, Maris Armasu, Sebastian M Auro, Kirsi Bjonnes, Andrew Chasman, Daniel I Chen, Shufeng Ford, Ian Franceschini, Nora Gieger, Christian Grace, Christopher Gustafsson, Stefan Huang, Jie Hwang, Shih-Jen Kim, Yun Kyoung Kleber, Marcus E Lau, King Wai Lu, Xiangfeng Lu, Yingchang Lyytikäinen, Leo-Pekka Mihailov, Evelin Morrison, Alanna C Pervjakova, Natalia Qu, Liming Rose, Lynda M Salfati, Elias Saxena, Richa Scholz, Markus Smith, Albert V Tikkanen, Emmi Uitterlinden, Andre Yang, Xueli Zhang, Weihua Zhao, Wei de Andrade, Mariza de Vries, Paul S van Zuydam, Natalie R Anand, Sonia S Bertram, Lars Beutner, Frank Dedoussis, George Frossard, Philippe Gauguier, Dominique Goodall, Alison H Gottesman, Omri Haber, Marc Han, Bok-Ghee Huang, Jianfeng Jalilzadeh, Shapour Kessler, Thorsten König, Inke R Lannfelt, Lars Lieb, Wolfgang Lind, Lars Lindgren, Cecilia M Lokki, Marja-Liisa Magnusson, Patrik K Mallick, Nadeem H Mehra, Narinder Meitinger, Thomas Memon, Fazal-ur-Rehman Morris, Andrew P Nieminen, Markku S Pedersen, Nancy L Peters, Annette Rallidis, Loukianos S Rasheed, Asif Samuel, Maria Shah, Svati H Sinisalo, Juha Stirrups, Kathleen E Trompet, Stella Wang, Laiyuan Zaman, Khan S Ardissino, Diego Boerwinkle, Eric Borecki, Ingrid B Bottinger, Erwin P Buring, Julie E Chambers, John C Collins, Rory Cupples, L Adrienne Danesh, John Demuth, Ilja Elosua, Roberto Epstein, Stephen E Esko, Tõnu Feitosa, Mary F Franco, Oscar H Franzosi, Maria Grazia Granger, Christopher B Gu, Dongfeng Gudnason, Vilmundur Hall, Alistair S Hamsten, Anders Harris, Tamara B Hazen, Stanley L Hengstenberg, Christian Hofman, Albert Ingelsson, Erik Iribarren, Carlos Jukema, J Wouter Karhunen, Pekka J Kim, Bong-Jo Kooner, Jaspal S Kullo, Iftikhar J Lehtimäki, Terho Loos, Ruth J F Melander, Olle Metspalu, Andres März, Winfried Palmer, Colin N Perola, Markus Quertermous, Thomas Rader, Daniel J Ridker, Paul M Ripatti, Samuli Roberts, Robert Salomaa, Veikko Sanghera, Dharambir K Schwartz, Stephen M Seedorf, Udo Stewart, Alexandre F Stott, David J Thiery, Joachim Zalloua, Pierre A O’Donnell, Christopher J Reilly, Muredach P Assimes, Themistocles L Thompson, John R Erdmann, Jeanette Clarke, Robert Watkins, Hugh Kathiresan, Sekar McPherson, Ruth Deloukas, Panos Schunkert, Heribert Samani, Nilesh J Farrall, Martin A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease |
| title | A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease |
| title_full | A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease |
| title_fullStr | A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease |
| title_full_unstemmed | A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease |
| title_short | A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease |
| title_sort | comprehensive 1000 genomes-based genome-wide association meta-analysis of coronary artery disease |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589895/ https://www.ncbi.nlm.nih.gov/pubmed/26343387 http://dx.doi.org/10.1038/ng.3396 |
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