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Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction

c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat ci...

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Autores principales: Ahn, Ji Yun, Tae, Hyun-Jin, Cho, Jeong-Hwi, Kim, In Hye, Ahn, Ji Hyeon, Park, Joon Ha, Kim, Dong Won, Cho, Jun Hwi, Won, Moo-Ho, Hong, Seongkweon, Lee, Jae-Chul, Seo, Jeong Yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590237/
https://www.ncbi.nlm.nih.gov/pubmed/26487852
http://dx.doi.org/10.4103/1673-5374.162757
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author Ahn, Ji Yun
Tae, Hyun-Jin
Cho, Jeong-Hwi
Kim, In Hye
Ahn, Ji Hyeon
Park, Joon Ha
Kim, Dong Won
Cho, Jun Hwi
Won, Moo-Ho
Hong, Seongkweon
Lee, Jae-Chul
Seo, Jeong Yeol
author_facet Ahn, Ji Yun
Tae, Hyun-Jin
Cho, Jeong-Hwi
Kim, In Hye
Ahn, Ji Hyeon
Park, Joon Ha
Kim, Dong Won
Cho, Jun Hwi
Won, Moo-Ho
Hong, Seongkweon
Lee, Jae-Chul
Seo, Jeong Yeol
author_sort Ahn, Ji Yun
collection PubMed
description c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. Neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction.
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spelling pubmed-45902372015-10-20 Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction Ahn, Ji Yun Tae, Hyun-Jin Cho, Jeong-Hwi Kim, In Hye Ahn, Ji Hyeon Park, Joon Ha Kim, Dong Won Cho, Jun Hwi Won, Moo-Ho Hong, Seongkweon Lee, Jae-Chul Seo, Jeong Yeol Neural Regen Res Research Article c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. Neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction. Medknow Publications & Media Pvt Ltd 2015-08 /pmc/articles/PMC4590237/ /pubmed/26487852 http://dx.doi.org/10.4103/1673-5374.162757 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Ahn, Ji Yun
Tae, Hyun-Jin
Cho, Jeong-Hwi
Kim, In Hye
Ahn, Ji Hyeon
Park, Joon Ha
Kim, Dong Won
Cho, Jun Hwi
Won, Moo-Ho
Hong, Seongkweon
Lee, Jae-Chul
Seo, Jeong Yeol
Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction
title Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction
title_full Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction
title_fullStr Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction
title_full_unstemmed Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction
title_short Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction
title_sort activation of immediate-early response gene c-fos protein in the rat paralimbic cortices after myocardial infarction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590237/
https://www.ncbi.nlm.nih.gov/pubmed/26487852
http://dx.doi.org/10.4103/1673-5374.162757
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