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Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction
c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat ci...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590237/ https://www.ncbi.nlm.nih.gov/pubmed/26487852 http://dx.doi.org/10.4103/1673-5374.162757 |
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author | Ahn, Ji Yun Tae, Hyun-Jin Cho, Jeong-Hwi Kim, In Hye Ahn, Ji Hyeon Park, Joon Ha Kim, Dong Won Cho, Jun Hwi Won, Moo-Ho Hong, Seongkweon Lee, Jae-Chul Seo, Jeong Yeol |
author_facet | Ahn, Ji Yun Tae, Hyun-Jin Cho, Jeong-Hwi Kim, In Hye Ahn, Ji Hyeon Park, Joon Ha Kim, Dong Won Cho, Jun Hwi Won, Moo-Ho Hong, Seongkweon Lee, Jae-Chul Seo, Jeong Yeol |
author_sort | Ahn, Ji Yun |
collection | PubMed |
description | c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. Neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction. |
format | Online Article Text |
id | pubmed-4590237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45902372015-10-20 Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction Ahn, Ji Yun Tae, Hyun-Jin Cho, Jeong-Hwi Kim, In Hye Ahn, Ji Hyeon Park, Joon Ha Kim, Dong Won Cho, Jun Hwi Won, Moo-Ho Hong, Seongkweon Lee, Jae-Chul Seo, Jeong Yeol Neural Regen Res Research Article c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. Neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction. Medknow Publications & Media Pvt Ltd 2015-08 /pmc/articles/PMC4590237/ /pubmed/26487852 http://dx.doi.org/10.4103/1673-5374.162757 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Ahn, Ji Yun Tae, Hyun-Jin Cho, Jeong-Hwi Kim, In Hye Ahn, Ji Hyeon Park, Joon Ha Kim, Dong Won Cho, Jun Hwi Won, Moo-Ho Hong, Seongkweon Lee, Jae-Chul Seo, Jeong Yeol Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction |
title | Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction |
title_full | Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction |
title_fullStr | Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction |
title_full_unstemmed | Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction |
title_short | Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction |
title_sort | activation of immediate-early response gene c-fos protein in the rat paralimbic cortices after myocardial infarction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590237/ https://www.ncbi.nlm.nih.gov/pubmed/26487852 http://dx.doi.org/10.4103/1673-5374.162757 |
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