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Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590238/ https://www.ncbi.nlm.nih.gov/pubmed/26487853 http://dx.doi.org/10.4103/1673-5374.162758 |
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author | Ran, Qi-shan Yu, Yun-hu Fu, Xiao-hong Wen, Yuan-chao |
author_facet | Ran, Qi-shan Yu, Yun-hu Fu, Xiao-hong Wen, Yuan-chao |
author_sort | Ran, Qi-shan |
collection | PubMed |
description | The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells. Suppression of the Notch signaling pathway with Notch1 or Jagged1 siRNAs reduced the migratory capacity, invasiveness and angiogenic ability of endothelial progenitor cells. Activation of the Notch signaling pathway in vivo in a rat model of mild traumatic brain injury promoted neurovascular repair. These findings suggest that the activation of the Notch signaling pathway promotes blood vessel formation and tissue repair after brain trauma. |
format | Online Article Text |
id | pubmed-4590238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-45902382015-10-20 Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury Ran, Qi-shan Yu, Yun-hu Fu, Xiao-hong Wen, Yuan-chao Neural Regen Res Research Article The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells. Suppression of the Notch signaling pathway with Notch1 or Jagged1 siRNAs reduced the migratory capacity, invasiveness and angiogenic ability of endothelial progenitor cells. Activation of the Notch signaling pathway in vivo in a rat model of mild traumatic brain injury promoted neurovascular repair. These findings suggest that the activation of the Notch signaling pathway promotes blood vessel formation and tissue repair after brain trauma. Medknow Publications & Media Pvt Ltd 2015-08 /pmc/articles/PMC4590238/ /pubmed/26487853 http://dx.doi.org/10.4103/1673-5374.162758 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Ran, Qi-shan Yu, Yun-hu Fu, Xiao-hong Wen, Yuan-chao Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury |
title | Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury |
title_full | Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury |
title_fullStr | Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury |
title_full_unstemmed | Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury |
title_short | Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury |
title_sort | activation of the notch signaling pathway promotes neurovascular repair after traumatic brain injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590238/ https://www.ncbi.nlm.nih.gov/pubmed/26487853 http://dx.doi.org/10.4103/1673-5374.162758 |
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