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Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury

The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using...

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Autores principales: Ran, Qi-shan, Yu, Yun-hu, Fu, Xiao-hong, Wen, Yuan-chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590238/
https://www.ncbi.nlm.nih.gov/pubmed/26487853
http://dx.doi.org/10.4103/1673-5374.162758
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author Ran, Qi-shan
Yu, Yun-hu
Fu, Xiao-hong
Wen, Yuan-chao
author_facet Ran, Qi-shan
Yu, Yun-hu
Fu, Xiao-hong
Wen, Yuan-chao
author_sort Ran, Qi-shan
collection PubMed
description The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells. Suppression of the Notch signaling pathway with Notch1 or Jagged1 siRNAs reduced the migratory capacity, invasiveness and angiogenic ability of endothelial progenitor cells. Activation of the Notch signaling pathway in vivo in a rat model of mild traumatic brain injury promoted neurovascular repair. These findings suggest that the activation of the Notch signaling pathway promotes blood vessel formation and tissue repair after brain trauma.
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spelling pubmed-45902382015-10-20 Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury Ran, Qi-shan Yu, Yun-hu Fu, Xiao-hong Wen, Yuan-chao Neural Regen Res Research Article The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury. Therefore, in the present study, we controlled the Notch signaling pathway using overexpression and knockdown constructs. Activation of the Notch signaling pathway by Notch1 or Jagged1 overexpression enhanced the migration, invasiveness and angiogenic ability of endothelial progenitor cells. Suppression of the Notch signaling pathway with Notch1 or Jagged1 siRNAs reduced the migratory capacity, invasiveness and angiogenic ability of endothelial progenitor cells. Activation of the Notch signaling pathway in vivo in a rat model of mild traumatic brain injury promoted neurovascular repair. These findings suggest that the activation of the Notch signaling pathway promotes blood vessel formation and tissue repair after brain trauma. Medknow Publications & Media Pvt Ltd 2015-08 /pmc/articles/PMC4590238/ /pubmed/26487853 http://dx.doi.org/10.4103/1673-5374.162758 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Ran, Qi-shan
Yu, Yun-hu
Fu, Xiao-hong
Wen, Yuan-chao
Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
title Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
title_full Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
title_fullStr Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
title_full_unstemmed Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
title_short Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury
title_sort activation of the notch signaling pathway promotes neurovascular repair after traumatic brain injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590238/
https://www.ncbi.nlm.nih.gov/pubmed/26487853
http://dx.doi.org/10.4103/1673-5374.162758
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