Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC(50) value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC(50), 32.5 µmol/L) in t...

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Detalles Bibliográficos
Autores principales: Uchida, Ryuji, Ishikawa, Seiko, Tomoda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590298/
https://www.ncbi.nlm.nih.gov/pubmed/26579376
http://dx.doi.org/10.1016/j.apsb.2013.12.008
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author Uchida, Ryuji
Ishikawa, Seiko
Tomoda, Hiroshi
author_facet Uchida, Ryuji
Ishikawa, Seiko
Tomoda, Hiroshi
author_sort Uchida, Ryuji
collection PubMed
description 2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC(50) value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC(50), 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.
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spelling pubmed-45902982015-11-17 Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol Uchida, Ryuji Ishikawa, Seiko Tomoda, Hiroshi Acta Pharm Sin B Original Article 2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC(50) value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC(50), 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells. Elsevier 2014-04 2014-03-21 /pmc/articles/PMC4590298/ /pubmed/26579376 http://dx.doi.org/10.1016/j.apsb.2013.12.008 Text en © 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ Open access under CC BY-NC-ND license.(http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Uchida, Ryuji
Ishikawa, Seiko
Tomoda, Hiroshi
Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
title Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
title_full Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
title_fullStr Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
title_full_unstemmed Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
title_short Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
title_sort inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590298/
https://www.ncbi.nlm.nih.gov/pubmed/26579376
http://dx.doi.org/10.1016/j.apsb.2013.12.008
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AT ishikawaseiko inhibitionoftyrosinaseactivityandmelaninepigmentationby2hydroxytyrosol
AT tomodahiroshi inhibitionoftyrosinaseactivityandmelaninepigmentationby2hydroxytyrosol

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