Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells’ osteogenic differentiation

Recent studies have indicated that statins induce osteogenic differentiation both in vitro and in vivo. The molecular mechanism of statin-stimulated osteogenesis is unknown. Activation of RhoA signaling increases cytoskeletal tension, which plays a crucial role in the osteogenic differentiation of m...

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Detalles Bibliográficos
Autores principales: Tai, I-Chun, Wang, Yao-Hsien, Chen, Chung-Hwan, Chuang, Shu-Chun, Chang, Je-Ken, Ho, Mei-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590348/
https://www.ncbi.nlm.nih.gov/pubmed/26451103
http://dx.doi.org/10.2147/IJN.S84273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590348/
https://www.ncbi.nlm.nih.gov/pubmed/26451103
http://dx.doi.org/10.2147/IJN.S84273

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