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Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells’ osteogenic differentiation

Recent studies have indicated that statins induce osteogenic differentiation both in vitro and in vivo. The molecular mechanism of statin-stimulated osteogenesis is unknown. Activation of RhoA signaling increases cytoskeletal tension, which plays a crucial role in the osteogenic differentiation of m...

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Detalles Bibliográficos
Autores principales:	Tai, I-Chun, Wang, Yao-Hsien, Chen, Chung-Hwan, Chuang, Shu-Chun, Chang, Je-Ken, Ho, Mei-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590348/ https://www.ncbi.nlm.nih.gov/pubmed/26451103 http://dx.doi.org/10.2147/IJN.S84273

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