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Prevalence of celiac disease in adult type 1 patients with diabetes
OBJECTIVES: Celiac disease, an autoimmune disease, is related to immune mediated intolerance to gluten. Some studies suggest that Celiac Disease was 20 times more frequent in type 1 patients with diabetes. The objective of our study was to evaluate the prevalence of celiac disease in hospital based...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590365/ https://www.ncbi.nlm.nih.gov/pubmed/26430419 http://dx.doi.org/10.12669/pjms.314.7206 |
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author | Dogan, Burcu Oner, Can Bayramicli, Oya Uygur Yorulmaz, Elif Feyizoglu, Guneş Oguz, Aytekin |
author_facet | Dogan, Burcu Oner, Can Bayramicli, Oya Uygur Yorulmaz, Elif Feyizoglu, Guneş Oguz, Aytekin |
author_sort | Dogan, Burcu |
collection | PubMed |
description | OBJECTIVES: Celiac disease, an autoimmune disease, is related to immune mediated intolerance to gluten. Some studies suggest that Celiac Disease was 20 times more frequent in type 1 patients with diabetes. The objective of our study was to evaluate the prevalence of celiac disease in hospital based type 1 diabetic adults. METHODS: Our study was carried out retrospectively in Medeniyet University Goztepe Training and Educational Hospital in Istanbul between 2012–2013. The cohort comprised 482 type 1 patients with diabetes attending the diabetes outpatient clinic. The data were analyzed by SPSS 10.5 package program. Student’s t tests is used for comparative analyses. A p-value less than 0.05 was considered statistically significant. RESULTS: The cohort included 482 type 1 patients with diabetes. Fifty seven of them were not evaluated for Endomysium antibody positivity. Fifteen of the remaining 425 patients were positive for anti endomysial antibody (3.5%). The prevalence of biopsy proven celiac disease was 2.3% (10/425). There was no significant difference between Endomysial antibody positive and negative groups in regard of age, sex, or duration of the disease. CONCLUSION: This study confirms that the celiac disease is common in type 1 diabetic patients. Since a small proportion of celiac patients are symptomatic this disorder should be screened in all adult type 1 patients with diabetes by antiendomysium antibody. |
format | Online Article Text |
id | pubmed-4590365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-45903652015-10-01 Prevalence of celiac disease in adult type 1 patients with diabetes Dogan, Burcu Oner, Can Bayramicli, Oya Uygur Yorulmaz, Elif Feyizoglu, Guneş Oguz, Aytekin Pak J Med Sci Original Article OBJECTIVES: Celiac disease, an autoimmune disease, is related to immune mediated intolerance to gluten. Some studies suggest that Celiac Disease was 20 times more frequent in type 1 patients with diabetes. The objective of our study was to evaluate the prevalence of celiac disease in hospital based type 1 diabetic adults. METHODS: Our study was carried out retrospectively in Medeniyet University Goztepe Training and Educational Hospital in Istanbul between 2012–2013. The cohort comprised 482 type 1 patients with diabetes attending the diabetes outpatient clinic. The data were analyzed by SPSS 10.5 package program. Student’s t tests is used for comparative analyses. A p-value less than 0.05 was considered statistically significant. RESULTS: The cohort included 482 type 1 patients with diabetes. Fifty seven of them were not evaluated for Endomysium antibody positivity. Fifteen of the remaining 425 patients were positive for anti endomysial antibody (3.5%). The prevalence of biopsy proven celiac disease was 2.3% (10/425). There was no significant difference between Endomysial antibody positive and negative groups in regard of age, sex, or duration of the disease. CONCLUSION: This study confirms that the celiac disease is common in type 1 diabetic patients. Since a small proportion of celiac patients are symptomatic this disorder should be screened in all adult type 1 patients with diabetes by antiendomysium antibody. Professional Medical Publications 2015 /pmc/articles/PMC4590365/ /pubmed/26430419 http://dx.doi.org/10.12669/pjms.314.7206 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dogan, Burcu Oner, Can Bayramicli, Oya Uygur Yorulmaz, Elif Feyizoglu, Guneş Oguz, Aytekin Prevalence of celiac disease in adult type 1 patients with diabetes |
title | Prevalence of celiac disease in adult type 1 patients with diabetes |
title_full | Prevalence of celiac disease in adult type 1 patients with diabetes |
title_fullStr | Prevalence of celiac disease in adult type 1 patients with diabetes |
title_full_unstemmed | Prevalence of celiac disease in adult type 1 patients with diabetes |
title_short | Prevalence of celiac disease in adult type 1 patients with diabetes |
title_sort | prevalence of celiac disease in adult type 1 patients with diabetes |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590365/ https://www.ncbi.nlm.nih.gov/pubmed/26430419 http://dx.doi.org/10.12669/pjms.314.7206 |
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