A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells

Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counterpart of MM. Here, integrating proteomics...

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Detalles Bibliográficos
Autores principales: Milan, Enrico, Perini, Tommaso, Resnati, Massimo, Orfanelli, Ugo, Oliva, Laura, Raimondi, Andrea, Cascio, Paolo, Bachi, Angela, Marcatti, Magda, Ciceri, Fabio, Cenci, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Translational Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590585/
https://www.ncbi.nlm.nih.gov/pubmed/26043024
http://dx.doi.org/10.1080/15548627.2015.1052928

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