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Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival

Most research involving alcohol and cancer concerns the relationship between alcohol consumption and cancer risk and the mechanisms of carcinogenesis. This review relates the amount and duration of alcohol intake in humans and in animal models of cancer to tumor growth, angiogenesis, invasion, metas...

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Detalles Bibliográficos
Autores principales: Meadows, Gary G., Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590626/
https://www.ncbi.nlm.nih.gov/pubmed/26695753
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author Meadows, Gary G.
Zhang, Hui
author_facet Meadows, Gary G.
Zhang, Hui
author_sort Meadows, Gary G.
collection PubMed
description Most research involving alcohol and cancer concerns the relationship between alcohol consumption and cancer risk and the mechanisms of carcinogenesis. This review relates the amount and duration of alcohol intake in humans and in animal models of cancer to tumor growth, angiogenesis, invasion, metastasis, immune response, and host survival in specific types and subtypes of cancer. Research on the influence of alcohol drinking on human cancer patients is limited. Although there is more information in animal models of cancer, many aspects still are ill defined. More research is needed to define the mechanisms that underlie the role of alcohol on cancer progression in both animals and humans. Activation of the immune system can play a positive role in keeping cancer under control, but this also can facilitate cancer progression. Additionally, a functional immune system is required for cancer patients to achieve an optimal response to conventional chemotherapy. Insight into the underlying mechanisms of these interactions could lead to effective immunotherapeutic approaches to treat alcoholics with cancer. Defining the epigenetic mechanisms that modulate cancer progression also has great potential for the development of new treatment options not only for treating alcoholics with cancer but also for treating other alcohol-induced diseases.
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spelling pubmed-45906262015-10-02 Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival Meadows, Gary G. Zhang, Hui Alcohol Res Feature Most research involving alcohol and cancer concerns the relationship between alcohol consumption and cancer risk and the mechanisms of carcinogenesis. This review relates the amount and duration of alcohol intake in humans and in animal models of cancer to tumor growth, angiogenesis, invasion, metastasis, immune response, and host survival in specific types and subtypes of cancer. Research on the influence of alcohol drinking on human cancer patients is limited. Although there is more information in animal models of cancer, many aspects still are ill defined. More research is needed to define the mechanisms that underlie the role of alcohol on cancer progression in both animals and humans. Activation of the immune system can play a positive role in keeping cancer under control, but this also can facilitate cancer progression. Additionally, a functional immune system is required for cancer patients to achieve an optimal response to conventional chemotherapy. Insight into the underlying mechanisms of these interactions could lead to effective immunotherapeutic approaches to treat alcoholics with cancer. Defining the epigenetic mechanisms that modulate cancer progression also has great potential for the development of new treatment options not only for treating alcoholics with cancer but also for treating other alcohol-induced diseases. National Institute on Alcohol Abuse and Alcoholism 2015 /pmc/articles/PMC4590626/ /pubmed/26695753 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Feature
Meadows, Gary G.
Zhang, Hui
Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
title Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
title_full Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
title_fullStr Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
title_full_unstemmed Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
title_short Effects of Alcohol on Tumor Growth, Metastasis, Immune Response, and Host Survival
title_sort effects of alcohol on tumor growth, metastasis, immune response, and host survival
topic Feature
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590626/
https://www.ncbi.nlm.nih.gov/pubmed/26695753
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