The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux

Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy. We uncovered that KRAS mutant (KRAS(mut)) CRC is uniquely sensitive to treatment with recombinant L...

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Detalles Bibliográficos
Autores principales: Wiersma, Valerie R, de Bruyn, Marco, Wei, Yunwei, van Ginkel, Robert J, Hirashima, Mitsuomi, Niki, Toshiro, Nishi, Nozomu, Zhou, Jin, Pouwels, Simon D, Samplonius, Douwe F, Nijman, Hans W, Eggleton, Paul, Helfrich, Wijnand, Bremer, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590647/
https://www.ncbi.nlm.nih.gov/pubmed/26086204
http://dx.doi.org/10.1080/15548627.2015.1063767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590647/
https://www.ncbi.nlm.nih.gov/pubmed/26086204
http://dx.doi.org/10.1080/15548627.2015.1063767

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