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Can formulation and drug delivery reduce attrition during drug discovery and development—review of feasibility, benefits and challenges
Drug discovery and development has become longer and costlier process. The fear of failure and stringent regulatory review process is driving pharmaceutical companies towards “me too” drugs and improved generics (505(b) (2)) fillings. The discontinuance of molecules at late stage clinical trials is...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590717/ https://www.ncbi.nlm.nih.gov/pubmed/26579359 http://dx.doi.org/10.1016/j.apsb.2013.12.003 |