Fundamental aspects of solid dispersion technology for poorly soluble drugs

The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug–polymer two-component system, the drug–polymer interaction is the determining factor in its design and performance. In this review, we summarize our c...

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Detalles Bibliográficos
Autores principales: Huang, Yanbin, Dai, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590721/
https://www.ncbi.nlm.nih.gov/pubmed/26579360
http://dx.doi.org/10.1016/j.apsb.2013.11.001
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author Huang, Yanbin
Dai, Wei-Guo
author_facet Huang, Yanbin
Dai, Wei-Guo
author_sort Huang, Yanbin
collection PubMed
description The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug–polymer two-component system, the drug–polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology.
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spelling pubmed-45907212015-11-17 Fundamental aspects of solid dispersion technology for poorly soluble drugs Huang, Yanbin Dai, Wei-Guo Acta Pharm Sin B Review The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug–polymer two-component system, the drug–polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology. Elsevier 2014-02 2013-12-05 /pmc/articles/PMC4590721/ /pubmed/26579360 http://dx.doi.org/10.1016/j.apsb.2013.11.001 Text en © 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Review
Huang, Yanbin
Dai, Wei-Guo
Fundamental aspects of solid dispersion technology for poorly soluble drugs
title Fundamental aspects of solid dispersion technology for poorly soluble drugs
title_full Fundamental aspects of solid dispersion technology for poorly soluble drugs
title_fullStr Fundamental aspects of solid dispersion technology for poorly soluble drugs
title_full_unstemmed Fundamental aspects of solid dispersion technology for poorly soluble drugs
title_short Fundamental aspects of solid dispersion technology for poorly soluble drugs
title_sort fundamental aspects of solid dispersion technology for poorly soluble drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590721/
https://www.ncbi.nlm.nih.gov/pubmed/26579360
http://dx.doi.org/10.1016/j.apsb.2013.11.001
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