Kidney–targeted drug delivery systems

Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular car...

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Detalles Bibliográficos
Autores principales: Zhou, Peng, Sun, Xun, Zhang, Zhirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590725/
https://www.ncbi.nlm.nih.gov/pubmed/26579362
http://dx.doi.org/10.1016/j.apsb.2013.12.005
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author Zhou, Peng
Sun, Xun
Zhang, Zhirong
author_facet Zhou, Peng
Sun, Xun
Zhang, Zhirong
author_sort Zhou, Peng
collection PubMed
description Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney. New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney.
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spelling pubmed-45907252015-11-17 Kidney–targeted drug delivery systems Zhou, Peng Sun, Xun Zhang, Zhirong Acta Pharm Sin B Review Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney. New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney. Elsevier 2014-02 2014-01-23 /pmc/articles/PMC4590725/ /pubmed/26579362 http://dx.doi.org/10.1016/j.apsb.2013.12.005 Text en © 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Review
Zhou, Peng
Sun, Xun
Zhang, Zhirong
Kidney–targeted drug delivery systems
title Kidney–targeted drug delivery systems
title_full Kidney–targeted drug delivery systems
title_fullStr Kidney–targeted drug delivery systems
title_full_unstemmed Kidney–targeted drug delivery systems
title_short Kidney–targeted drug delivery systems
title_sort kidney–targeted drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590725/
https://www.ncbi.nlm.nih.gov/pubmed/26579362
http://dx.doi.org/10.1016/j.apsb.2013.12.005
work_keys_str_mv AT zhoupeng kidneytargeteddrugdeliverysystems
AT sunxun kidneytargeteddrugdeliverysystems
AT zhangzhirong kidneytargeteddrugdeliverysystems

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