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Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants. OBJECTIVES: We investigated the relationship between maternal PBDE levels and thyro...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
NLM-Export
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590759/ https://www.ncbi.nlm.nih.gov/pubmed/25893858 http://dx.doi.org/10.1289/ehp.1408996 |
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author | Vuong, Ann M. Webster, Glenys M. Romano, Megan E. Braun, Joseph M. Zoeller, R. Thomas Hoofnagle, Andrew N. Sjödin, Andreas Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin |
author_facet | Vuong, Ann M. Webster, Glenys M. Romano, Megan E. Braun, Joseph M. Zoeller, R. Thomas Hoofnagle, Andrew N. Sjödin, Andreas Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin |
author_sort | Vuong, Ann M. |
collection | PubMed |
description | BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants. OBJECTIVES: We investigated the relationship between maternal PBDE levels and thyroid hormone concentrations in maternal and cord sera. METHODS: We used data from the Health Outcomes and Measures of the Environment (HOME)Study, a prospective birth cohort of 389 pregnant women in Cincinnati, Ohio, who were enrolled from 2003 through 2006 and delivered singleton infants. Maternal serum PBDE concentrations were measured at enrollment (16 ± 3 weeks of gestation). Thyroid hormone concentrations were measured in maternal serum at enrollment (n = 187) and in cord serum samples (n = 256). RESULTS: Median maternal serum concentrations of BDEs 28 and 47 were 1.0 and 19.1 ng/g lipid, respectively. A 10-fold increase in BDEs 28 and 47 concentrations was associated with a 0.85-μg/dL [95% confidence interval (CI): 0.05, 1.64] and 0.82-μg/dL (95% CI: 0.12, 1.51) increase in maternal total thyroxine concentrations (TT(4)), respectively. Both congeners were also positively associated with maternal free thyroxine (FT(4)). We also observed positive associations between BDE-47 and maternal total and free triiodothyronine (TT(3) and FT(3)). A 10-fold increase in BDE-28 was associated with elevated FT(3) concentrations (β = 0.14 pg/mL; 95% CI: 0.02, 0.26). In contrast, maternal PBDE levels were not associated with thyroid hormone concentrations in cord serum. CONCLUSIONS: These findings suggest that maternal PBDE exposure, particularly BDEs 28 and 47, are associated with maternal concentrations of T(4) and T(3) during pregnancy. CITATION: Vuong AM, Webster GM, Romano ME, Braun JM, Zoeller RT, Hoofnagle AN, Sjödin A, Yolton K, Lanphear BP, Chen A. 2015. Maternal polybrominated diphenyl ether (PBDE) exposure and thyroid hormones in maternal and cord sera: the HOME Study, Cincinnati, USA. Environ Health Perspect 123:1079–1085; http://dx.doi.org/10.1289/ehp.1408996 |
format | Online Article Text |
id | pubmed-4590759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | NLM-Export |
record_format | MEDLINE/PubMed |
spelling | pubmed-45907592015-10-19 Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA Vuong, Ann M. Webster, Glenys M. Romano, Megan E. Braun, Joseph M. Zoeller, R. Thomas Hoofnagle, Andrew N. Sjödin, Andreas Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin Environ Health Perspect Children's Health BACKGROUND: Polybrominated diphenyl ethers (PBDEs) reduce blood concentrations of thyroid hormones in laboratory animals, but it is unclear whether PBDEs disrupt thyroid hormones in pregnant women or newborn infants. OBJECTIVES: We investigated the relationship between maternal PBDE levels and thyroid hormone concentrations in maternal and cord sera. METHODS: We used data from the Health Outcomes and Measures of the Environment (HOME)Study, a prospective birth cohort of 389 pregnant women in Cincinnati, Ohio, who were enrolled from 2003 through 2006 and delivered singleton infants. Maternal serum PBDE concentrations were measured at enrollment (16 ± 3 weeks of gestation). Thyroid hormone concentrations were measured in maternal serum at enrollment (n = 187) and in cord serum samples (n = 256). RESULTS: Median maternal serum concentrations of BDEs 28 and 47 were 1.0 and 19.1 ng/g lipid, respectively. A 10-fold increase in BDEs 28 and 47 concentrations was associated with a 0.85-μg/dL [95% confidence interval (CI): 0.05, 1.64] and 0.82-μg/dL (95% CI: 0.12, 1.51) increase in maternal total thyroxine concentrations (TT(4)), respectively. Both congeners were also positively associated with maternal free thyroxine (FT(4)). We also observed positive associations between BDE-47 and maternal total and free triiodothyronine (TT(3) and FT(3)). A 10-fold increase in BDE-28 was associated with elevated FT(3) concentrations (β = 0.14 pg/mL; 95% CI: 0.02, 0.26). In contrast, maternal PBDE levels were not associated with thyroid hormone concentrations in cord serum. CONCLUSIONS: These findings suggest that maternal PBDE exposure, particularly BDEs 28 and 47, are associated with maternal concentrations of T(4) and T(3) during pregnancy. CITATION: Vuong AM, Webster GM, Romano ME, Braun JM, Zoeller RT, Hoofnagle AN, Sjödin A, Yolton K, Lanphear BP, Chen A. 2015. Maternal polybrominated diphenyl ether (PBDE) exposure and thyroid hormones in maternal and cord sera: the HOME Study, Cincinnati, USA. Environ Health Perspect 123:1079–1085; http://dx.doi.org/10.1289/ehp.1408996 NLM-Export 2015-04-17 2015-10 /pmc/articles/PMC4590759/ /pubmed/25893858 http://dx.doi.org/10.1289/ehp.1408996 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Children's Health Vuong, Ann M. Webster, Glenys M. Romano, Megan E. Braun, Joseph M. Zoeller, R. Thomas Hoofnagle, Andrew N. Sjödin, Andreas Yolton, Kimberly Lanphear, Bruce P. Chen, Aimin Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA |
title | Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA |
title_full | Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA |
title_fullStr | Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA |
title_full_unstemmed | Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA |
title_short | Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA |
title_sort | maternal polybrominated diphenyl ether (pbde) exposure and thyroid hormones in maternal and cord sera: the home study, cincinnati, usa |
topic | Children's Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590759/ https://www.ncbi.nlm.nih.gov/pubmed/25893858 http://dx.doi.org/10.1289/ehp.1408996 |
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