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Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs
A series of 3-[2′-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[2′-(3(″)-chloro-2(″)-oxo-4(″)-substitutedphenylazetidin-1(″)-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[2′-(2(″)-substitutedphenyl-4(″)-oxo-1(″),3(″)-thiazolidin-3(″)-yl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590821/ https://www.ncbi.nlm.nih.gov/pubmed/26556002 http://dx.doi.org/10.1155/2013/907525 |
Sumario: | A series of 3-[2′-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[2′-(3(″)-chloro-2(″)-oxo-4(″)-substitutedphenylazetidin-1(″)-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[2′-(2(″)-substitutedphenyl-4(″)-oxo-1(″),3(″)-thiazolidin-3(″)-yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17–22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, (1)H NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic activities. |
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