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Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats

Anaesthesia was induced in West African Dwarf (WAD) goats using different combinations of propofol (P), xylazine (X), and ketamine (K), and the biochemical effect of the drugs determined. Twenty male (WAD) goats were randomly assigned to five treatment groups viz. Control (C) (2.5 mL IV normal salin...

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Autores principales: Celestine Okwudili, Ukwueze, Athanasius Chinedu, Eze, Jonas Anayo, Ona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590834/
https://www.ncbi.nlm.nih.gov/pubmed/26464940
http://dx.doi.org/10.1155/2014/758581
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author Celestine Okwudili, Ukwueze
Athanasius Chinedu, Eze
Jonas Anayo, Ona
author_facet Celestine Okwudili, Ukwueze
Athanasius Chinedu, Eze
Jonas Anayo, Ona
author_sort Celestine Okwudili, Ukwueze
collection PubMed
description Anaesthesia was induced in West African Dwarf (WAD) goats using different combinations of propofol (P), xylazine (X), and ketamine (K), and the biochemical effect of the drugs determined. Twenty male (WAD) goats were randomly assigned to five treatment groups viz. Control (C) (2.5 mL IV normal saline); group K + X (5 mg/kg IV ketamine + 0.05 mg/kg IV xylazine), group P + X (5 mg/kg IV propofol + 0.05 mg/kg IV xylazine), group P + K (propofol 5 mg/kg IV + ketamine 5 mg/kg IV), and group P + K + X (propofol 2.5 mg/kg IV + ketamine 2.5 mg/kg IV + xylazine 0.05 mg/kg IV), respectively. There was increase (P < 0.05) in blood glucose in K + X, P + X and P + K + X. The serum cortisol level increased (P < 0.05) in all groups except in P + X. ALT value increased (P < 0.05) in K + X, P + K, and P + K + X. BUN increased (P < 0.05) in K + X but decreased (P < 0.05) in P + K + X. There was no significant variation (P > 0.05) in serum creatinine. These biochemical changes were transient. P + K + X would be the best drug combinations considering the biochemical parameter measured. However, data on blood glucose, ALT, BUN, and cortisol levels in an anaesthsized goat should be interpreted with caution in order to avoid erroneous interpretation in these animals.
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spelling pubmed-45908342015-10-13 Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats Celestine Okwudili, Ukwueze Athanasius Chinedu, Eze Jonas Anayo, Ona J Vet Med Research Article Anaesthesia was induced in West African Dwarf (WAD) goats using different combinations of propofol (P), xylazine (X), and ketamine (K), and the biochemical effect of the drugs determined. Twenty male (WAD) goats were randomly assigned to five treatment groups viz. Control (C) (2.5 mL IV normal saline); group K + X (5 mg/kg IV ketamine + 0.05 mg/kg IV xylazine), group P + X (5 mg/kg IV propofol + 0.05 mg/kg IV xylazine), group P + K (propofol 5 mg/kg IV + ketamine 5 mg/kg IV), and group P + K + X (propofol 2.5 mg/kg IV + ketamine 2.5 mg/kg IV + xylazine 0.05 mg/kg IV), respectively. There was increase (P < 0.05) in blood glucose in K + X, P + X and P + K + X. The serum cortisol level increased (P < 0.05) in all groups except in P + X. ALT value increased (P < 0.05) in K + X, P + K, and P + K + X. BUN increased (P < 0.05) in K + X but decreased (P < 0.05) in P + K + X. There was no significant variation (P > 0.05) in serum creatinine. These biochemical changes were transient. P + K + X would be the best drug combinations considering the biochemical parameter measured. However, data on blood glucose, ALT, BUN, and cortisol levels in an anaesthsized goat should be interpreted with caution in order to avoid erroneous interpretation in these animals. Hindawi Publishing Corporation 2014 2014-09-11 /pmc/articles/PMC4590834/ /pubmed/26464940 http://dx.doi.org/10.1155/2014/758581 Text en Copyright © 2014 Ukwueze Celestine Okwudili et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Celestine Okwudili, Ukwueze
Athanasius Chinedu, Eze
Jonas Anayo, Ona
Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats
title Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats
title_full Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats
title_fullStr Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats
title_full_unstemmed Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats
title_short Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats
title_sort biochemical effects of xylazine, propofol, and ketamine in west african dwarf goats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590834/
https://www.ncbi.nlm.nih.gov/pubmed/26464940
http://dx.doi.org/10.1155/2014/758581
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