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Uric Acid Levels in Normotensive Children of Hypertensive Parents

This study evaluated uric acid concentrations in normotensive children of parents with hypertension. Eighty normotensive children from families with and without a history of essential hypertension were included. Concentrations of lipid parameters and uric acid were compared. Demographic and anthropo...

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Autores principales: Yildirim, Ali, Keles, Fatma, Kosger, Pelin, Ozdemir, Gokmen, Ucar, Birsen, Kilic, Zubeyir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590931/
https://www.ncbi.nlm.nih.gov/pubmed/26464873
http://dx.doi.org/10.1155/2015/747082
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author Yildirim, Ali
Keles, Fatma
Kosger, Pelin
Ozdemir, Gokmen
Ucar, Birsen
Kilic, Zubeyir
author_facet Yildirim, Ali
Keles, Fatma
Kosger, Pelin
Ozdemir, Gokmen
Ucar, Birsen
Kilic, Zubeyir
author_sort Yildirim, Ali
collection PubMed
description This study evaluated uric acid concentrations in normotensive children of parents with hypertension. Eighty normotensive children from families with and without a history of essential hypertension were included. Concentrations of lipid parameters and uric acid were compared. Demographic and anthropometric characteristics were similar in the groups. Systolic and diastolic blood pressure were higher in the normotensive children of parents with hypertension without statistically significant difference (P > 0.05). Uric acid concentrations were higher in the normotensive children of parents with hypertension (4.61 versus 3.57 mg/dL, P < 0.01). Total cholesterol and triglyceride concentrations were similar in the two groups. Systolic and diastolic blood pressure were significantly higher in control children aged >10 years (P < 0.01). Uric acid levels were significantly higher in all children with more pronounced difference after age 10 of years (P < 0.001). Positive correlations were found between the level of serum uric acid and age, body weight, body mass index, and systolic and diastolic blood pressure in the normotensive children of parents. The higher uric acid levels in the normotensive children of hypertensive parents suggest that uric acid may be a predeterminant of hypertension. Monitoring of uric acid levels in these children may allow for prevention or earlier treatment of future hypertension.
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spelling pubmed-45909312015-10-13 Uric Acid Levels in Normotensive Children of Hypertensive Parents Yildirim, Ali Keles, Fatma Kosger, Pelin Ozdemir, Gokmen Ucar, Birsen Kilic, Zubeyir Int J Chronic Dis Research Article This study evaluated uric acid concentrations in normotensive children of parents with hypertension. Eighty normotensive children from families with and without a history of essential hypertension were included. Concentrations of lipid parameters and uric acid were compared. Demographic and anthropometric characteristics were similar in the groups. Systolic and diastolic blood pressure were higher in the normotensive children of parents with hypertension without statistically significant difference (P > 0.05). Uric acid concentrations were higher in the normotensive children of parents with hypertension (4.61 versus 3.57 mg/dL, P < 0.01). Total cholesterol and triglyceride concentrations were similar in the two groups. Systolic and diastolic blood pressure were significantly higher in control children aged >10 years (P < 0.01). Uric acid levels were significantly higher in all children with more pronounced difference after age 10 of years (P < 0.001). Positive correlations were found between the level of serum uric acid and age, body weight, body mass index, and systolic and diastolic blood pressure in the normotensive children of parents. The higher uric acid levels in the normotensive children of hypertensive parents suggest that uric acid may be a predeterminant of hypertension. Monitoring of uric acid levels in these children may allow for prevention or earlier treatment of future hypertension. Hindawi Publishing Corporation 2015 2015-08-24 /pmc/articles/PMC4590931/ /pubmed/26464873 http://dx.doi.org/10.1155/2015/747082 Text en Copyright © 2015 Ali Yildirim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yildirim, Ali
Keles, Fatma
Kosger, Pelin
Ozdemir, Gokmen
Ucar, Birsen
Kilic, Zubeyir
Uric Acid Levels in Normotensive Children of Hypertensive Parents
title Uric Acid Levels in Normotensive Children of Hypertensive Parents
title_full Uric Acid Levels in Normotensive Children of Hypertensive Parents
title_fullStr Uric Acid Levels in Normotensive Children of Hypertensive Parents
title_full_unstemmed Uric Acid Levels in Normotensive Children of Hypertensive Parents
title_short Uric Acid Levels in Normotensive Children of Hypertensive Parents
title_sort uric acid levels in normotensive children of hypertensive parents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590931/
https://www.ncbi.nlm.nih.gov/pubmed/26464873
http://dx.doi.org/10.1155/2015/747082
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