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Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant

The aim of this study was to clarify patterns of serum concentrations of dioxins in the employees of a waste incineration plant and to estimate elimination rates and half-lives of serum dioxin isomers, and the maximum serum concentrations of dioxin isomers at the time of plant shutdown. Sixteen subj...

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Autores principales: YAMAMOTO, Kenya, KUDO, Mitsuhiro, ARITO, Heihachiro, OGAWA, Yasutaka, TAKATA, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Occupational Safety and Health, Japan 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591138/
https://www.ncbi.nlm.nih.gov/pubmed/26118856
http://dx.doi.org/10.2486/indhealth.2015-0008
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author YAMAMOTO, Kenya
KUDO, Mitsuhiro
ARITO, Heihachiro
OGAWA, Yasutaka
TAKATA, Tsutomu
author_facet YAMAMOTO, Kenya
KUDO, Mitsuhiro
ARITO, Heihachiro
OGAWA, Yasutaka
TAKATA, Tsutomu
author_sort YAMAMOTO, Kenya
collection PubMed
description The aim of this study was to clarify patterns of serum concentrations of dioxins in the employees of a waste incineration plant and to estimate elimination rates and half-lives of serum dioxin isomers, and the maximum serum concentrations of dioxin isomers at the time of plant shutdown. Sixteen subjects participating 3 times or more in annual health examinations during an 8-yr period from 2000 to 2007 were recruited for this study. Serum concentrations of dioxins expressed as TEQ/g lipid decreased gradually after plant shutdown with the highest decrease observed in polychlorinated dibenzofurans (PCDFs) followed by polychlorinated deibenzo-p-dioxins (PCDDs) and then coplanar PCBs. The serum toxic equivalency (TEQ) concentrations of PCDF and PCDD congeners in the employees were higher than those in the general population survey by the Ministry of the Environment, Japan, whereas the serum concentrations of coplanar PCBs were similar to those in the general population. The estimated half-lives and elimination rates of PCDDs and PCDFs in the highly exposed workers increased compared with the moderately exposed workers. The estimated geometric mean serum concentrations of PCDDs, PCDFs and total dioxins at the time of plant shutdown were 35, 53 and 107 pg TEQ/g lipid, respectively.
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spelling pubmed-45911382015-10-26 Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant YAMAMOTO, Kenya KUDO, Mitsuhiro ARITO, Heihachiro OGAWA, Yasutaka TAKATA, Tsutomu Ind Health Original Article The aim of this study was to clarify patterns of serum concentrations of dioxins in the employees of a waste incineration plant and to estimate elimination rates and half-lives of serum dioxin isomers, and the maximum serum concentrations of dioxin isomers at the time of plant shutdown. Sixteen subjects participating 3 times or more in annual health examinations during an 8-yr period from 2000 to 2007 were recruited for this study. Serum concentrations of dioxins expressed as TEQ/g lipid decreased gradually after plant shutdown with the highest decrease observed in polychlorinated dibenzofurans (PCDFs) followed by polychlorinated deibenzo-p-dioxins (PCDDs) and then coplanar PCBs. The serum toxic equivalency (TEQ) concentrations of PCDF and PCDD congeners in the employees were higher than those in the general population survey by the Ministry of the Environment, Japan, whereas the serum concentrations of coplanar PCBs were similar to those in the general population. The estimated half-lives and elimination rates of PCDDs and PCDFs in the highly exposed workers increased compared with the moderately exposed workers. The estimated geometric mean serum concentrations of PCDDs, PCDFs and total dioxins at the time of plant shutdown were 35, 53 and 107 pg TEQ/g lipid, respectively. National Institute of Occupational Safety and Health, Japan 2015-06-26 2015-09 /pmc/articles/PMC4591138/ /pubmed/26118856 http://dx.doi.org/10.2486/indhealth.2015-0008 Text en ©2015 National Institute of Occupational Safety and Health http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original Article
YAMAMOTO, Kenya
KUDO, Mitsuhiro
ARITO, Heihachiro
OGAWA, Yasutaka
TAKATA, Tsutomu
Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant
title Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant
title_full Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant
title_fullStr Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant
title_full_unstemmed Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant
title_short Isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant
title_sort isomer pattern and elimination of dioxins in workers exposed at a municipal waste incineration plant
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591138/
https://www.ncbi.nlm.nih.gov/pubmed/26118856
http://dx.doi.org/10.2486/indhealth.2015-0008
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