Synthesis and antiproliferative activity of pterostilbene and [Formula: see text] -methoxy pterostilbene Mannich base derivatives against Hela cells

ABSTRACT: Fourteen novel pterostilbene (1) and [Formula: see text] -methoxy pterostilbene (2) Mannich base derivatives (3–16) were synthesized via the microwave-assisted Mannich reaction of 1 or 2 with various secondary amines and formaldehyde. The regioselectivity of the reaction occurred preferent...

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Detalles Bibliográficos
Autores principales: Liu, Chongyang, Dong, Linpei, Wang, Shengchun, Wang, Qiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Full-Length Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591201/
https://www.ncbi.nlm.nih.gov/pubmed/26162533
http://dx.doi.org/10.1007/s11030-015-9615-1
Descripción
Sumario:ABSTRACT: Fourteen novel pterostilbene (1) and [Formula: see text] -methoxy pterostilbene (2) Mannich base derivatives (3–16) were synthesized via the microwave-assisted Mannich reaction of 1 or 2 with various secondary amines and formaldehyde. The regioselectivity of the reaction occurred preferentially at [Formula: see text] position of the B-ring of stilbene. The biological testing results showed that all the target compounds exhibit antiproliferative activity against Hela cells from [Formula: see text] –[Formula: see text] . Compounds 1–3, 7, 11–13, and 16 displayed higher (lower [Formula: see text] values) activity than the positive control cisplatin [Formula: see text] . GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11030-015-9615-1) contains supplementary material, which is available to authorized users.

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