Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction

The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine double minute 2) via a direct protein—protein interact...

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Detalles Bibliográficos
Autores principales: Pettersson, Mariell, Quant, Maria, Min, Jaeki, Iconaru, Luigi, Kriwacki, Richard W., Waddell, M. Brett, Guy, R. Kiplin, Luthman, Kristina, Grøtli, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591261/
https://www.ncbi.nlm.nih.gov/pubmed/26427060
http://dx.doi.org/10.1371/journal.pone.0137867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591261/
https://www.ncbi.nlm.nih.gov/pubmed/26427060
http://dx.doi.org/10.1371/journal.pone.0137867

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