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PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy
Neuropathic pain treatment remains challenging due to ineffective therapy and resistance to opioid analgesia. Mitogen-activated protein kinase kinase (MAPKK) have been identified as the crucial regulators of pro- and antinociceptive factors. We used PD98059, an inhibitor of the MAPKK family members...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591269/ https://www.ncbi.nlm.nih.gov/pubmed/26426693 http://dx.doi.org/10.1371/journal.pone.0138583 |