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PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy

Neuropathic pain treatment remains challenging due to ineffective therapy and resistance to opioid analgesia. Mitogen-activated protein kinase kinase (MAPKK) have been identified as the crucial regulators of pro- and antinociceptive factors. We used PD98059, an inhibitor of the MAPKK family members...

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Detalles Bibliográficos
Autores principales:	Rojewska, Ewelina, Popiolek-Barczyk, Katarzyna, Kolosowska, Natalia, Piotrowska, Anna, Zychowska, Magdalena, Makuch, Wioletta, Przewlocka, Barbara, Mika, Joanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591269/ https://www.ncbi.nlm.nih.gov/pubmed/26426693 http://dx.doi.org/10.1371/journal.pone.0138583

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