Cargando…

Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study

BACKGROUND: The risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure. METHODS AND FINDINGS: This study identified 3 mutually exc...

Descripción completa

Detalles Bibliográficos
Autores principales: Chou, Yin-Yi, Lai, Kuo-Lung, Chen, Der-Yuan, Lin, Ching-Heng, Chen, Hsin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591281/
https://www.ncbi.nlm.nih.gov/pubmed/26426533
http://dx.doi.org/10.1371/journal.pone.0139693
_version_ 1782393049724223488
author Chou, Yin-Yi
Lai, Kuo-Lung
Chen, Der-Yuan
Lin, Ching-Heng
Chen, Hsin-Hua
author_facet Chou, Yin-Yi
Lai, Kuo-Lung
Chen, Der-Yuan
Lin, Ching-Heng
Chen, Hsin-Hua
author_sort Chou, Yin-Yi
collection PubMed
description BACKGROUND: The risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure. METHODS AND FINDINGS: This study identified 3 mutually exclusive cohorts using the 1999–2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between PD and the risk of incident RA. All patients with PD in 2000 were identified from the database of all enrollees as the PD cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any periodontal disease (PO) during 1999–2010 were selected as the non-PO cohort. Individuals who were not included in the non-PO cohort and received dental scaling (DS) no more than two times per year during 1999–2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between PD exposure and RA development. In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56–2.29 and 1.09–1.87, respectively). For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57–2.30 and 1.09–1.67, respectively). CONCLUSION: PD was associated with an increased risk of RA development.
format Online
Article
Text
id pubmed-4591281
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-45912812015-10-09 Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study Chou, Yin-Yi Lai, Kuo-Lung Chen, Der-Yuan Lin, Ching-Heng Chen, Hsin-Hua PLoS One Research Article BACKGROUND: The risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure. METHODS AND FINDINGS: This study identified 3 mutually exclusive cohorts using the 1999–2010 Taiwanese National Health Insurance Research Database (NHIRD) to investigate the association between PD and the risk of incident RA. All patients with PD in 2000 were identified from the database of all enrollees as the PD cohort. From the representative database of 1,000,000 enrollees randomly selected in 2010 (LHID2010), individuals without any periodontal disease (PO) during 1999–2010 were selected as the non-PO cohort. Individuals who were not included in the non-PO cohort and received dental scaling (DS) no more than two times per year during 1999–2010 were selected as the DS cohort from LHID2010. Using cox proportional regression analysis, hazard ratios (HRs) with 95% confidence intervals (Cis) were calculated to quantify the association between PD exposure and RA development. In the three-group comparison using the non-PO cohort as reference, we found that the risk of RA was higher in the PD and DS cohorts (HRs, 1.89 and 1.43; 95% CIs, 1.56–2.29 and 1.09–1.87, respectively). For comparisons between two cohorts, the PD cohort had a higher risk of RA than the non-PO and DS cohorts (HRs, 1.91 and 1.35; 95% CIs, 1.57–2.30 and 1.09–1.67, respectively). CONCLUSION: PD was associated with an increased risk of RA development. Public Library of Science 2015-10-01 /pmc/articles/PMC4591281/ /pubmed/26426533 http://dx.doi.org/10.1371/journal.pone.0139693 Text en © 2015 Chou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chou, Yin-Yi
Lai, Kuo-Lung
Chen, Der-Yuan
Lin, Ching-Heng
Chen, Hsin-Hua
Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study
title Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study
title_full Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study
title_fullStr Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study
title_full_unstemmed Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study
title_short Rheumatoid Arthritis Risk Associated with Periodontitis Exposure: A Nationwide, Population-Based Cohort Study
title_sort rheumatoid arthritis risk associated with periodontitis exposure: a nationwide, population-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591281/
https://www.ncbi.nlm.nih.gov/pubmed/26426533
http://dx.doi.org/10.1371/journal.pone.0139693
work_keys_str_mv AT chouyinyi rheumatoidarthritisriskassociatedwithperiodontitisexposureanationwidepopulationbasedcohortstudy
AT laikuolung rheumatoidarthritisriskassociatedwithperiodontitisexposureanationwidepopulationbasedcohortstudy
AT chenderyuan rheumatoidarthritisriskassociatedwithperiodontitisexposureanationwidepopulationbasedcohortstudy
AT linchingheng rheumatoidarthritisriskassociatedwithperiodontitisexposureanationwidepopulationbasedcohortstudy
AT chenhsinhua rheumatoidarthritisriskassociatedwithperiodontitisexposureanationwidepopulationbasedcohortstudy